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Posts Tagged ‘epigenetics’

What affects fertility?

Total fertility rate

Nutrition for fertility and pregnancy is included in our functional approach to male and female fertility nutrition. We treat with care for the individual and also the couple, at Susannah Makram Clinics

What 5 Factors affect fertility?

Total fertility rate – What affects fertility?

1. Poor nutrition is the biggest factor that affects fertility. Nutrition during pregnancy is seen by measurements taken of a growing a healthy baby. 4 to 6 months before trying to conceive couples are building the foundation. A woman’s body is ready to provide a nourishing environment for growing a baby.

The 9 months of pregnancy are now considered by a lot of researchers to be the most consequential period of our lives. Before we are even born, this time is most important in determining our health for the rest of our life.   [tweetthis]Before we’re even born, this time is most important in determining lifetime #health [/tweetthis]

Babies that are born at a low birth weight, which is primarily determined by maternal nutrition, have a significantly higher risk for diseases. These disease include heart disease, diabetes, hypertension, kidney disease. Later in life the risk for these diseases rises independently of lifestyle risk factors.

For healthy sperm

Obesity in men affects fertility because accumulation of fat in the thighs increases the temperature of the scrotum. This in turn adversely impacts sperm quality. Infertile men have lower concentrations of DHA and EPA in their sperm. They are unlikely to be eating eating enough of the long chain omega-3 fats.

2. This is followed closely by stress

Moura-Ramos, M., Gameiro, S., Canavarro, M., Soares, I. and Santos, T. (2012). The indirect effect of contextual factors on the emotional distress of infertile couplesPsychology and Health, 27(5), 533-549. (10.1080/08870446.2011.598231
Barnea ER, Tal J. Stress-related reproductive failure. J In Vitro Fert Embryo Transf. 1991 Feb;8(1):15–23.

50% of infertility is caused by male factors. Oxidative stress is caused primary by excess intake of industrial seed oils, stress and lack of physical activity can damage sperm quality.

The biggest factor keeping women from getting pregnant is the modern lifestyle and it is a big problem because already 1 in 7 women have trouble conceiving. A study out of the UK that suggested that this number could rise to 1 in 3 by 2020

What affects fertility?

What affects fertility?

What affects fertility? Other Factors:

3.  Environmental toxins – there are a lot of toxins that end up being endocrine disrupters. These throw the hormones out of whack and that makes it difficult for women to get pregnant.

4.  Medications like birth control – A medical term has been coined Post Birth Control Syndrome  or ‘post-pill amenorrhea’

In some women, it may take some time for their menstrual cycle (and subsequently their fertility) to return to normal when they stop taking birth control pills. The main symptom is a rather obvious one. A woman is unable to conceive even after she has discontinued the use of the birth control pill. Generally speaking, your period should resume within three months. If you have a history of irregular periods and took the pill to regulate your cycle, you may not have a period for many months after you stop taking the pill. If you do not have a period within 6 months, you should see your doctor to determine the cause.

What affects fertility?

5. Medications that affect hormones, metabolism, and synthesis i.e. modern lifestyle  

50% of infertility is caused by male factors. Men should be testosterone dominant not oestrogen dominant and oestrogen dominance in men leads to hypogonadism and infertility. The lower the sperm count and the poorer the sperm quality, the longer it will take to get pregnant. The omega6/omega3 balance is probably one of the biggest factors in male infertility.

What is fertility?

What is fertility?

Side effects of long-term NSAID usage. Long term use or a high dosage of NSAIDs, such as ibuprofen or aspirin, can make it more difficult for you to conceive. Medicines used for chemotherapy (a treatment for cancer) can sometimes cause ovarian failure. This means your ovaries will no longer be able to function properly. Ovarian failure can be permanent.

Side effects of spironolactone. Fertility should recover around two months after you stop taking spironolactone for fluid retention.

Side effects of Neuroleptic medicines. Neuroleptic medicines are antipsychotic medicines often used to treat psychosis. They can sometimes cause missed periods or infertility.

DNA Test For Weight Loss – Results

Stubborn Belly fat

Why spend 5 hours in the gym? Imagine achieving your optimal MET (metabolic equivalent) taking the dog for a walk?!
Our laboratory DNA test analyses 4 genes that have been clinically proven to affect your response to diet and exercise.
Stubborn fat e.g. belly fat is a different kind of fat. The result of our DNA Diet may help you. Here’s how:

Is it safe?

YOU GAIN sensible advice so you won’t sacrifice important nutrients or indeed your own time by exercising unnecessarily.

Why are we storing fat around our middle, stubborn fat around our thighs, our hips or upper arms? Stubborn belly fat is a different kind of fat that leads to all kinds of health complications. Taking this DNA test doesn’t just highlight WHY diets have failed us in the past….

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat

 

Feeling discomfort, low in energy, lacking confidence that comes with stubborn fat and being tired all the time?

DNA Test For Weight Loss

DNA Diet Test analyses for healthy weight loss at Susannah Makram Clinics gives clear:

(1) % values for optimal fats, carbs, proteins to consume daily for healthy weight loss.
(2) Suggestion for which proteins, carbs, fats you should consume daily for your healthy weight loss
(3) Clear instructions on how to achieve your optimal MET on a day by day, week by week basis

Our genes might hold the key to understanding why diets have failed in the past. We call the study of how this works epigenetics.

Why take the DNA Diet Test for Weight Loss at Susannah Makram Clinics

From your buccal swab sample we have used a process, called the Polymerase Chain Reaction (PCR). This copies the DNA of your genes many times over. This means we can generate sufficient quantities to analyse your genetic material. This is not uncomfortable at all and is all over very quickly!


The DNA Diet test for weight loss lets us identify unique DNA sequences in some of your genes. You get these results within 7-10 working days in hard copy or email, however you prefer to receive them.


Identifying unique DNA sequences

Certain changes (polymorphisms) in these genes have been studied in detail. Evidence correlates these polymorphisms with your weight management and response to specific food. See these in your DNA Test For Weight Loss Results. (e.g. below)


 

DNA Test For Weight Loss

Taking the buccal swab sample

  • The term ‘Buccal swab’ refers to a DNA collection process involving cells taken from the cheek (from the inside mouth area).
  • Buccal Swabs are sterile. Therefore, it is essential to preserve a sterile test environment. They are produced for medical use. Unless you are allergic to cotton, they should not cause an irritation.
  • An advantage of a Buccal swab is that it allows you to take a DNA sample, in a non invasive way, that is accurate.
  • Buccal swabs should be taken when your mouth is empty. It is best if you swallow first, then swab the inside of your cheek for approximately 30 seconds. The feel is an impression as hard as if you were brushing your teeth.
  • Having a cold should not cause contamination or interferences to your Buccal Swab Sample of DNA testing

Your DNA Test For Weight Loss Results Explained

Not only will the test determine the percentage quantity of fat, protein and the amount of carbohydrate you should be eating but also the type of fat exactly and what type of carbohydrate exactly.

whatisacarb2

whatisafat

Four primary diet and lifestyle factors

i) exercise, ii) obesity risk, iii) sensitivity to carbohydrates and iv) sensitivity to saturated fats.

Your DNA Test For Weight Loss makes a complete assessment of weight management, both environmental factors (diet and lifestyle) and previous medical history need to be considered in conjunction with the accompanying genetic profile.


Only gene variants that have a beneficial, moderate or high impact on metabolic processes are analysed. These are described in detail in your report. Your report is delivered to you once the laboratory investigation on your buccal swab test has been processed. These gene variants will have impact or a mild impact to your personalised nutrition The required alteration or tweaking is made to your Naturopathic Portfolio

Gene Name for each Area of Activity is reported. The areas of activity of interest in the DNA Test for Weight Loss are:

DNA Weight Loss

DNA Weight Loss

Metabolism and Absorption    FABP2 Ala54Thr PPARG Pro12Ala     ADRB2 Arg16Gly     ADRB2 Gln27Glu   APOA5 T>C
Fat metabolism, obesity and satiety    APOA2 -265 T>C
Regulation of metabolism and feeding behaviour    MC4R T>C
Insulin sensitivity and regulation of energy intake  FTO T>A   TCF7L2 C>T
Exercise responsiveness     ADBR3 Trp64Arg
Circadian rhythms     CLOCK T>C
Fat storage      PLIN G>A
Inflammation     TNFA -308 G>A
Taste sensitivity    TAS1R2       SLC2A2 (encoding GLUT2)
Addictions and Overeating      DRD2

Genetic variations for each named gene are stated. Your Results and Gene Impact are in printed out for you in the list above.

Each gene tested has an impact score in your DNA Weight Loss Report

NO IMPACT
LOW IMPACT
MEDIUM IMPACT
HIGH IMPACT

These results are only a guideline. You are as unique as your DNA.  Eat. Drink. Take. Make. Your Naturopathic Portfolio is Safe, Clinical, Practical, Effective.


Safe, clinical, practical and effective.


Call  020 7060 3181