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Sperm DNA testing UK

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Sperm DNA

Testing Sperm DNA damage  can help couples optimise diet and lifestyle for fertility. DNA fragmentation testing, The Tunel assay and sperm chromatin dispersion Halo test will be compared. Read on. At Susannah Makram Clinics we offer the best type of sperm DNA fragmentation testing  – a type of male fertility testing. At consultation we address the pros and cons of test so you can decide. Ask us how. 0207 060 3181

Couples – who benefits from a sperm DNA test?

Sperm DNA testing UK consultation . We provide essential information regrading lifestyle and our environment based on your health and fertility story so far. We outline what use of the test means for you and your partner. We can suggest which clinics guide couples to their bespoke treatment, for their particular needs. These include couples with:

  • Unexplained infertility
  • Men with normal semen by semen analysis (normal sperm count and sperm motility) prior to IVF
  • Couples who have had unsuccessful IVF 
  • Couple with no success using ICSI
  • Couples who have had miscarriages

Sperm DNA damage – Which Test?

The Comet assay – The SpermComet Test – Lewis Fertility testing at Susannah Makram Clinics

Extensive clinical trials and statistics that prove this test is the best indicator for, not only choosing the right treatment, but also to test when Sperm DNA Damage reversal IN THE FOUR PHASES is successful thus.

 

Sperm DNA testing Uk

All testing in and outside of the UK to measure sperm DNA damage are different. The Spermcomet test is described by Prof Lewis and was featured in Daily Mail recently. The current range of sperm DNA tests measure different aspects of DNA damage. The tests all have different sensitivities. The tests also provide information that may or may not provide couples with treatment advice.

The four tests most often used today are: 1) the Comet assay, 2) SCSA, 3) the terminal transferase dUTP nick end labeling (TUNEL) assay, and the 4) Sperm Chromatin Dispersion (SCD or Halo) test.


We want only the best for couple visiting our clinic for consultation. If we recommend the test we use data collected to actively reverse sperm DNA damage. this care pathway is unique for every couple at Susannah Makram Clinics. 


 

The Comet assay – The SpermComet Test

The comet assay is a second generation sperm DNA test. Unlike the other three tests, it quantifies the actual amount of DNA damage per sperm. Super DNSA testing UK – result guide can de found here.

One major advantage of this assay is that it uses only 5000 sperm. Therefore, it is suitable for the assessment of small samples left over from clinical use, or for samples where only a few sperm are available.

The Comet assay can measure both single and double strand breaks. With an additional step, the SpermComet can measure even altered bases.


This is useful because we do not yet know which types of DNA damage are most deleterious to male fertility.       [tweetthis]We do not yet know which types of #DNA damage are most deleterious to #malefertility. [/tweetthis]


The Comet is sensitive, repeatable and capable of detecting damage in every sperm. This is high sensitivity is evident of fertile donors. Since 2010, clinical thresholds for the diagnosis of male infertility and the prediction of successful IVF have been established.

At Susannah Makram Clinics we use The Comet Assay in our laboratory testing


 

The Sperm chromatin structure assay

The SCSA is a fluorescence cell sorter test which measures the susceptibility of sperm DNA to denaturation after exposure to heat or acid conditions.

The clinical threshold for this test is a DNA fragmentation index (DFI) of 30%- that means 30% of the sperm have damage (with quantification into moderate or high damage) and 70% have no detectable damage.

Couples with >30% damage are more likely to have success with ICSI than IVF

The TUNEL assay

The TUNEL assay detects ‘nicks’ (free ends of DNA) by incorporating fluorescent stained nucleotides. This allows the detection of single and double stranded damage.

The TUNEL has major potential but robust clinical thresholds have yet to be established.

The sperm chromatin dispersion (Halo) test

The Halo test is a ‘cheap and convenient’ kit form of sperm DNA testing. It is a simple and inexpensive assay, available in fertility labs for in house use.

Unlike all the other tests, the HALO measures the absence of damage, rather than the damaged DNA in sperm.

One limitation of the assay is that its low-density nucleoids are relatively faint, with less contrasting images.

To date, correlations have been observed between DNA and other sperm parameters. Few correlations between sperm DNA damage and ART outcomes have been established with the Halo test, even in large studies.

15 Fertility Rate Facts To Know Now

Fertility Rate – 15  Facts  – What You Need to Know Now If You Ever Want Kids

It’s likely you’re unsure of your current fertility rate. Modern times are affecting our fertility rates. Our fertility rates are subject to changing trends and patterns. We know lifestyle choices during pregnancy affect the health of your baby. What about food, exercise and other lifestyle choices we’re making today? Do they affect our fertility rate, our potential future?

These are choices we are making today.

“15 Fertility Rate Facts To Know Now”


‘One in six couples has problems starting a family’       [tweetthis hidden_hashtags=”#fertility #pregnancy”]’One in six couples has problems starting a family’ [/tweetthis]


In a word, yes. Lifestyle factors can affect a woman’s chances of getting pregnant. This is by natural and assisted conception. It’s not just women, male partners affect chances of pregnancy too. Your fertility rate or your current fertility profile should enable you to face facts.

Why Fertility Rates Are On The Decline

Let’s get clued up now. Here’s why:

  1. One in six couples has difficulty having a baby – in 40 per cent of these cases the difficulty is associated with the man.         [tweetthis]In 40% of #infertility cases, the cause, for 1 in 6 couples, is associated with the man[/tweetthis]

Equal responsibility is about sharing knowledge and open communication. 

  1. Timing is just about everything when it comes to fertility –

In a normal cycle of 28 days, the woman ovulates normally on day 14 (14 days after the start of menstruation). The most fertile day would be on day 14 and the most fertile week is that which goes from day 11 to 17.

  1. The medical definition of infertility is the failure to conceive following twelve months of regular unprotected intercourse After this time your GP will refer you for:

A blood test to measure ovulation is required. The most common cause of ovulation problems is polycystic ovaries.

Chlamydia can cause pelvic inflammatory disease and fertility problems. So this might be tested for also (vaginal swab or urine test). Male sperm count and motility are measured at this stage from a sperm sample.

  1. Secondary infertility accounts for 60 percent of infertility cases – that is, when a couple has trouble conceiving after they’ve already had a baby or more — is more common than primary infertility, when first-timers have trouble.
  1. Women are at their most fertile between the ages of 20-24

There are both advantages and disadvantages to giving birth at different ages. Overall, being healthy parents puts you in good stead.

 

Female Infertility

15 Fertility Rate Facts To Know Now

  1. Female fertility begins to decline at age 30.

If you are over 40, you may want to start your quest for a second pregnancy with a fertility expert on hand. Similarly, if your partner is over 40, you may want to get a specialist on board from the beginning.

  1. Sperm DNA damage has been identified as a major contributor to male infertility        [tweetthis]Sperm DNA damage has been identified as a major contributor to male #infertility[/tweetthis]

The quality and quantity of the sperm diminishes from the age of 25. Damage to sperm DNA (sperm DNA fragmentation) affects every fertility checkpoint and can increase the risk of miscarriage.

The SpermComet assay is a second generation sperm DNA test. It is the ONLY test that can measure the extent of damage in individual sperm.

  1. Men Do Have a Biological Clock

Males can produce viable sperm — and father babies — well into their AARP years. However, older men are more likely to have fertility issues. Also, due to dipping testosterone levels, there is a decrease in quantity and quality of sperm. Sperm strength, motility and other factors.

Male Fertility Testing

Male Fertility Testing

 

  1. More than half of all pregnancies conceived through IVF in women over age forty are produced through donor eggs. Egg freezing or (new techniques like) vitrification is not a taboo subject any more.

 

  1. Female infertility is typically caused by one or more of these factors:

Damage to fallopian tubes (tubal infertility)
Endometriosis
Uterine or cervical causes
Ovulation disorders

 

  1. Success in assisted conception is dependent on the quality of the sperm and eggs

Egg quality falls with age. Hence, one of the strongest predictors of whether an IVF cycle will be successful is the age of the woman. A major cause of this is the development of chromosomal abnormalities in the egg as it matures, which can in turn be passed on to the embryo.

Genetic screening is available to help choose the best embryo(s) to replace and thus increase the pregnancy rate.

 

  1. Cough medicine can help you get pregnant, laptops and briefs can impair sperm production. Saliva is a sperm Killer & position doesn’t really matter. Common Chemicals Are Fertility Inhibitors

Expectorants loosen up mucus in your chest but they are also able to loosen up cervical mucus – if antihistamine-free. Looser cervical mucus is easier for sperm to hitch a ride in!

Not all bodily fluids get along. In fact saliva is a sperm killer. The truth is most lubricants and massage oils are fertility unfriendly. So it is best to go without when you are baby making.

Some studies have shown that the now-infamous Bisphenol A (BPA) can decrease fertility in women. Perfluoronated chemicals (PFCs), used in Teflon, have also been shown to affect the menstrual cycle.

15 Fertility Rate Facts To Know Now Continued…

  1. Both Prescription & Recreational Drugs affect fertility as does smoking cigarettes

Some antidepressants (like SSRI’s) can raise a woman’s serum prolactin level. This can interfere with normal ovulation. Even certain antiemetic (anti-nausea) medications can alter prolactin levels.

Using any drugs, even cannabis, can affect the menstrual cycle. Heavier drugs like opiates have been shown to suppress the reproductive cycle. They affect the centers of the brain that control release of the female hormones.

Smoking cigarettes – even secondhand smoke – has been shown to reduce fertility time and time again.

 

When IVF Fails

When IVF Fails

 

  1. An Unhealthy body weight may prevent you from having children

Being overweight, obese or underweight can have negative consequences for one’s ability to conceive. This is because obesity can interfere with normal hormone function and fertility. The only treatment available to successfully reverse sperm DNA damage is largely dependent on two things. These are nutrition and nutritional supplementation.

  1. Fertility is a sensitive subject for a reason and there are support groups. Fertility and therapeutic counselling is also available for couples trying to conceive naturally. These are also there for individuals and couples using assisted fertility methods.

15 Fertility Rate Facts To Know Now

Susannah understands that when a couple hears a diagnosis of  ‘unexplained infertility’ it’s incredibly frustrating. When natural conception or assisted reproductive fertility treatment haven’t been successful, it’s difficult to hear. The most common assisted fertility treatment is IVF.  We put together 15 fertility rate facts to know now because you want to understand what the next steps are. You want to move forward from this, when ready. You should be able to discuss these steps and come to a decision together.


Nutrition impacts 80% of your modern lifestyle. This impacts every single factor affecting fertility. This goes for both men and women. If you  take ownership of your health you can make sure that the right changes impact you and your partner for the best.


 


Safe, clinical, practical and effective.


Call  020 7060 3181