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When IVF Fails

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Infertility Treatment

INFERTILITY CARE PATHWAYS depend on 1) WHEN infertility diagnosis made (2) age (3) your partner’s age (4) many personal preferences. When IVF fails we reassess these causes. At Susannah Makram Clinics we view infertility as a complete care pathway. That this may be supported by our individual body wellness is where we come in.

When IVF Fails

When IVF fails your decision to go ahead with the same treatment for infertility is usually put into question. This is a natural reaction to have.

In vitro fertilisation (IVF) is the most common ART technique. When IVF fails, the decision to continue with another IVF cycle, at the earliest possible time, is not one to take lightly. Assisted reproductive technology (ART) is any fertility treatment in which the egg and sperm are handled.
IVF involves stimulating and retrieving multiple mature eggs from a woman, fertilising them with a man’s sperm in a dish in a lab, and implanting the embryos in the uterus three to five days after fertilisation.

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When IVF Fails

IVF Success Rates

IVF-conceived babies now account for 2% all babies born in the UK.      [tweetthis]IVF-conceived babies now account for 2% all babies born in the UK[/tweetthis]

The success rate of ART is lower after age 35. This is according to new figures on infertility treatment us and outcomes. these figures are released annually by the Human Fertilisation and Embryology Authority (HFEA).

When choosing a fertility clinic carrying out IVF treatment The HFEA presents success rates for every licensed clinic.

Some women need just one or two therapies to restore fertility. It is possible that several different types of treatment may be needed before you are able to conceive.


GENETIC and CHROMOSOMAL issues causing FAILURE OF IMPLANTATION in IVF – The high rate of chromosomal abnormalities in human embryos.

  • As women age, the incidence of chromosomal abnormalities in mature eggs increases significantly. Studies have shown that starting in early 30s, the rate of chromosomal abnormalities in human eggs (and therefore in human embryos) starts to increase significantly.
  • The rate continues to increase with advancing female age. By mid-40s a very high percentage of human embryos are chromosomally abnormal (over 75%).
  • It’s believed that this is mainly due to problems with the spindle apparatus in the egg nucleus. The spindle is involved with properly lining up and segregating the chromosomes as the egg matures at the time of ovulation.
  • Older eggs have an inefficient spindle apparatus that does not line up the chromosome pairs properly. “Mistakes” are made when splitting pairs of chromosomes. This leads to eggs that don’t have the proper balance of 23 chromosomes – and will result in a chromosomally abnormal embryo if fertilised.
  • It has been shown that about 1% to 2% of human sperm are chromosomally abnormal on average – as compared to about 20% to 90% of human eggs (depending on female age).
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    When IVF Fails

PGS – preimplantation genetic screening can be done on embryos prior to transfer to evaluate chromosomal competence.

Other “genetic causes” of implantation failure

  • Implantation failure is probably caused by other genetic mutations sometimes. With a perfectly normal “karyotype” or chromosome complement.
  • There are tens of thousands of genes in the human genome. A lot of places where something can go wrong.
  • With time there will be genes discovered that are crucial for efficient embryo implantation. These will be both on the embryo side and on the uterine side. Perhaps they will involve the immune system as well.

INFERTILITY treatment involves commitment that is significantly financial, physical, psychological and time consuming. Male infertility treatment for general sexual problems or lack of healthy sperm at Susannah Makram Clinics use advanced male fertility diagnostics to outline effective treatment protocols for couple to choose from. Tests identify and support improvement for (normal sperm count and) poor sperm quality.

Your Naturopathic Portfolio to improve sperm quality at Susannah Makram Clinics supports ICSI if used in an IVF cycle as described.
FIND OUT MORE ABOUT FERTILITY TREATMENT ROUTES AND HOW SUPPORTING LIFESTYLE CHANGES CAN HELP COUPLES TODAY.

Female fertility continued 

Sperm DNA Fragmentation Testing

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When IVF Fails
MORE THAN 60,000 IVF CYCLES take place in Britain each year. Just 24% of these treatments lead to live births. At Susannah Makram Clinics we’re here to use information highlighted below. This helps map out a care pathway centred around optimising your health.    [tweetthis]There are >60,000 #IVF cycles in Britain p.a. Only 24% of these lead to live #births[/tweetthis]

When IVF Fails

IVF Implantation Failure. Why does in vitro fertilisation sometimes fail?

When IVF fails it’s a frustrating situation for couples and their fertility doctors. Sperm DNA Fragmentation Testing results can help be a guide for couples.

Why do we do sperm DNA fragmentation testing at Susannah Makram Clinics London?
Email from client: “We have followed your instructions and the Aneuploidy test went down from 60% to 14% which is a very good result. I feel fine and have lost weight…” — Mr. R (Dubai)

Before booking your appointment with Nutrition Expert Susannah for referral we’ll help assess the need for Sperm Fragmentation Testing. This way you know what to expect when you book your appointment with Susannah. Will this data be helpful in your case, on your fertility journey? The extent of this is covered in your initial consultation when a full history taken.
We use this test at Susannah Makram Clinics London – with use of previous reports and investigations and your medical case history. When it comes to helping you make nutrition and lifestyle changes we answer: How will these benefit you and your partner?
The SpermComet Test for Sperm DNA Fragmentation Testing helps couples decide whether IVF is best first or again. Sperm DNA fragmentation reports guide couples to help them map out their fertility treatment route. At Susannah Makram Clinics we’re here to use this information to map out a care pathway centred around optimising your health.
There is an equation we can use to illustrate the implantation process:

  • Embryo quality + receptivity of uterine lining = chance for implantation and pregnancy
  • We know that many human embryos will arrest (die) before day 5
  • Unfortunately, embryonic arrest also occurs after day 5
  • Some of the embryos that are transferred that ” look good” will die after they are placed in the uterus
  • This is the explanation for IVF failure in the large majority of cases
  • It is usually a weakness in the embryo that leads to failed implantation
  • On the average, only about 25% of transferred embryos continue to develop and become kids
  • This percentage of implanting embryos is greatly dependent on female age – see below
    • About 45% implant under age 35
    • About 15% implant at age 40-42

When IVF fails, couples often ask why the embryos did not stick. When IVF fails we ask why the uterus isn’t accepting the embryos. Rarely is the answer straightforward, unfortunately.

At Susannah Makram Clinics we feel passionately about this. We care greatly that information is provided to patients at all times. Especially in this difficult time, so time is not wasted and that right treatment is offered. We care to avoid heartache.

Unexplained infertility

Unexplained infertility is a frustrating conclusion for couples. It’s a very unsatisfactory diagnosis for couples and clinic alike. In our latest study we have shown that 80% of couples diagnosed with idiopathic infertility have sperm DNA damage (>25% damage per sperm).

This suggests that sperm DNA damage is the cause of infertility in a substantial number of men if we compare these levels of damage we reported in sperm of donor men with proven fertility

When IVF Fails

When IVF Fails

Sperm DNA Fragmentation Testing

WE KNOW:

The percentage of implanting embryos is greatly dependent on female age. Typically female age is the main factor responsible for unexplained infertility. This is especially the case after repeated failure of  IVF cycles. Find out more about this in detail here.

Which couples benefit from a sperm DNA test?

Sperm DNA testing will provide essential information on which clinics can guide couples to bespoke treatment for their particular needs. These include couples with:

  • Unexplained infertility
  • Men with normal semen by semen analysis prior to embarking on IVF
  • Couples who have had unsuccessful IVF
  • Couples who have had miscarriages

Sperm DNA Fragmentation Testing

We are testing Sperm DNA damage so we may guide couples with low damage to intrauterine insemination (IUI) or in vitro fertilization (IVF). We are pro patient choice.

Sperm DNA Fragmentation Testing

Sperm DNA Fragmentation Testing

 

Guiding couples with high DNA damage to ICSI and only couples who would not benefit from testing are advisable but ultimately it is the couples’ choice. With oligo-astheno-terato-zoospermia there is no treatment other than ICSI for couples. It helps to understand what this means. That is why we take the time to explain all options available to couples following any fertility results.

At Susannah Makram Clinics we use the SpermComet Test for Sperm DNA fragmentation testing. Find out why here


Safe, clinical, practical and effective.


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