Call  020 7060 3181


Navigation

Posts Tagged ‘Sperm DNA Testing’

Sperm DNA Fragmentation Testing

Posted on:

When IVF Fails
MORE THAN 60,000 IVF CYCLES take place in Britain each year. Just 24% of these treatments lead to live births. At Susannah Makram Clinics we’re here to use information highlighted below. This helps map out a care pathway centred around optimising your health.    [tweetthis]There are >60,000 #IVF cycles in Britain p.a. Only 24% of these lead to live #births[/tweetthis]

When IVF Fails

IVF Implantation Failure. Why does in vitro fertilisation sometimes fail?

When IVF fails it’s a frustrating situation for couples and their fertility doctors. Sperm DNA Fragmentation Testing results can help be a guide for couples.

Why do we do sperm DNA fragmentation testing at Susannah Makram Clinics London?
Email from client: “We have followed your instructions and the Aneuploidy test went down from 60% to 14% which is a very good result. I feel fine and have lost weight…” — Mr. R (Dubai)

Before booking your appointment with Nutrition Expert Susannah for referral we’ll help assess the need for Sperm Fragmentation Testing. This way you know what to expect when you book your appointment with Susannah. Will this data be helpful in your case, on your fertility journey? The extent of this is covered in your initial consultation when a full history taken.
We use this test at Susannah Makram Clinics London – with use of previous reports and investigations and your medical case history. When it comes to helping you make nutrition and lifestyle changes we answer: How will these benefit you and your partner?
The SpermComet Test for Sperm DNA Fragmentation Testing helps couples decide whether IVF is best first or again. Sperm DNA fragmentation reports guide couples to help them map out their fertility treatment route. At Susannah Makram Clinics we’re here to use this information to map out a care pathway centred around optimising your health.
There is an equation we can use to illustrate the implantation process:

  • Embryo quality + receptivity of uterine lining = chance for implantation and pregnancy
  • We know that many human embryos will arrest (die) before day 5
  • Unfortunately, embryonic arrest also occurs after day 5
  • Some of the embryos that are transferred that ” look good” will die after they are placed in the uterus
  • This is the explanation for IVF failure in the large majority of cases
  • It is usually a weakness in the embryo that leads to failed implantation
  • On the average, only about 25% of transferred embryos continue to develop and become kids
  • This percentage of implanting embryos is greatly dependent on female age – see below
    • About 45% implant under age 35
    • About 15% implant at age 40-42

When IVF fails, couples often ask why the embryos did not stick. When IVF fails we ask why the uterus isn’t accepting the embryos. Rarely is the answer straightforward, unfortunately.

At Susannah Makram Clinics we feel passionately about this. We care greatly that information is provided to patients at all times. Especially in this difficult time, so time is not wasted and that right treatment is offered. We care to avoid heartache.

Unexplained infertility

Unexplained infertility is a frustrating conclusion for couples. It’s a very unsatisfactory diagnosis for couples and clinic alike. In our latest study we have shown that 80% of couples diagnosed with idiopathic infertility have sperm DNA damage (>25% damage per sperm).

This suggests that sperm DNA damage is the cause of infertility in a substantial number of men if we compare these levels of damage we reported in sperm of donor men with proven fertility

When IVF Fails

When IVF Fails

Sperm DNA Fragmentation Testing

WE KNOW:

The percentage of implanting embryos is greatly dependent on female age. Typically female age is the main factor responsible for unexplained infertility. This is especially the case after repeated failure of  IVF cycles. Find out more about this in detail here.

Which couples benefit from a sperm DNA test?

Sperm DNA testing will provide essential information on which clinics can guide couples to bespoke treatment for their particular needs. These include couples with:

  • Unexplained infertility
  • Men with normal semen by semen analysis prior to embarking on IVF
  • Couples who have had unsuccessful IVF
  • Couples who have had miscarriages

Sperm DNA Fragmentation Testing

We are testing Sperm DNA damage so we may guide couples with low damage to intrauterine insemination (IUI) or in vitro fertilization (IVF). We are pro patient choice.

Sperm DNA Fragmentation Testing

Sperm DNA Fragmentation Testing

 

Guiding couples with high DNA damage to ICSI and only couples who would not benefit from testing are advisable but ultimately it is the couples’ choice. With oligo-astheno-terato-zoospermia there is no treatment other than ICSI for couples. It helps to understand what this means. That is why we take the time to explain all options available to couples following any fertility results.

At Susannah Makram Clinics we use the SpermComet Test for Sperm DNA fragmentation testing. Find out why here

15 Fertility Rate Facts To Know Now

Fertility Rate – 15  Facts  – What You Need to Know Now If You Ever Want Kids

It’s likely you’re unsure of your current fertility rate. Modern times are affecting our fertility rates. Our fertility rates are subject to changing trends and patterns. We know lifestyle choices during pregnancy affect the health of your baby. What about food, exercise and other lifestyle choices we’re making today? Do they affect our fertility rate, our potential future?

These are choices we are making today.

“15 Fertility Rate Facts To Know Now”


‘One in six couples has problems starting a family’       [tweetthis hidden_hashtags=”#fertility #pregnancy”]’One in six couples has problems starting a family’ [/tweetthis]


In a word, yes. Lifestyle factors can affect a woman’s chances of getting pregnant. This is by natural and assisted conception. It’s not just women, male partners affect chances of pregnancy too. Your fertility rate or your current fertility profile should enable you to face facts.

Why Fertility Rates Are On The Decline

Let’s get clued up now. Here’s why:

  1. One in six couples has difficulty having a baby – in 40 per cent of these cases the difficulty is associated with the man.         [tweetthis]In 40% of #infertility cases, the cause, for 1 in 6 couples, is associated with the man[/tweetthis]

Equal responsibility is about sharing knowledge and open communication. 

  1. Timing is just about everything when it comes to fertility –

In a normal cycle of 28 days, the woman ovulates normally on day 14 (14 days after the start of menstruation). The most fertile day would be on day 14 and the most fertile week is that which goes from day 11 to 17.

  1. The medical definition of infertility is the failure to conceive following twelve months of regular unprotected intercourse After this time your GP will refer you for:

A blood test to measure ovulation is required. The most common cause of ovulation problems is polycystic ovaries.

Chlamydia can cause pelvic inflammatory disease and fertility problems. So this might be tested for also (vaginal swab or urine test). Male sperm count and motility are measured at this stage from a sperm sample.

  1. Secondary infertility accounts for 60 percent of infertility cases – that is, when a couple has trouble conceiving after they’ve already had a baby or more — is more common than primary infertility, when first-timers have trouble.
  1. Women are at their most fertile between the ages of 20-24

There are both advantages and disadvantages to giving birth at different ages. Overall, being healthy parents puts you in good stead.

 

Female Infertility

15 Fertility Rate Facts To Know Now

  1. Female fertility begins to decline at age 30.

If you are over 40, you may want to start your quest for a second pregnancy with a fertility expert on hand. Similarly, if your partner is over 40, you may want to get a specialist on board from the beginning.

  1. Sperm DNA damage has been identified as a major contributor to male infertility        [tweetthis]Sperm DNA damage has been identified as a major contributor to male #infertility[/tweetthis]

The quality and quantity of the sperm diminishes from the age of 25. Damage to sperm DNA (sperm DNA fragmentation) affects every fertility checkpoint and can increase the risk of miscarriage.

The SpermComet assay is a second generation sperm DNA test. It is the ONLY test that can measure the extent of damage in individual sperm.

  1. Men Do Have a Biological Clock

Males can produce viable sperm — and father babies — well into their AARP years. However, older men are more likely to have fertility issues. Also, due to dipping testosterone levels, there is a decrease in quantity and quality of sperm. Sperm strength, motility and other factors.

Male Fertility Testing

Male Fertility Testing

 

  1. More than half of all pregnancies conceived through IVF in women over age forty are produced through donor eggs. Egg freezing or (new techniques like) vitrification is not a taboo subject any more.

 

  1. Female infertility is typically caused by one or more of these factors:

Damage to fallopian tubes (tubal infertility)
Endometriosis
Uterine or cervical causes
Ovulation disorders

 

  1. Success in assisted conception is dependent on the quality of the sperm and eggs

Egg quality falls with age. Hence, one of the strongest predictors of whether an IVF cycle will be successful is the age of the woman. A major cause of this is the development of chromosomal abnormalities in the egg as it matures, which can in turn be passed on to the embryo.

Genetic screening is available to help choose the best embryo(s) to replace and thus increase the pregnancy rate.

 

  1. Cough medicine can help you get pregnant, laptops and briefs can impair sperm production. Saliva is a sperm Killer & position doesn’t really matter. Common Chemicals Are Fertility Inhibitors

Expectorants loosen up mucus in your chest but they are also able to loosen up cervical mucus – if antihistamine-free. Looser cervical mucus is easier for sperm to hitch a ride in!

Not all bodily fluids get along. In fact saliva is a sperm killer. The truth is most lubricants and massage oils are fertility unfriendly. So it is best to go without when you are baby making.

Some studies have shown that the now-infamous Bisphenol A (BPA) can decrease fertility in women. Perfluoronated chemicals (PFCs), used in Teflon, have also been shown to affect the menstrual cycle.

15 Fertility Rate Facts To Know Now Continued…

  1. Both Prescription & Recreational Drugs affect fertility as does smoking cigarettes

Some antidepressants (like SSRI’s) can raise a woman’s serum prolactin level. This can interfere with normal ovulation. Even certain antiemetic (anti-nausea) medications can alter prolactin levels.

Using any drugs, even cannabis, can affect the menstrual cycle. Heavier drugs like opiates have been shown to suppress the reproductive cycle. They affect the centers of the brain that control release of the female hormones.

Smoking cigarettes – even secondhand smoke – has been shown to reduce fertility time and time again.

 

When IVF Fails

When IVF Fails

 

  1. An Unhealthy body weight may prevent you from having children

Being overweight, obese or underweight can have negative consequences for one’s ability to conceive. This is because obesity can interfere with normal hormone function and fertility. The only treatment available to successfully reverse sperm DNA damage is largely dependent on two things. These are nutrition and nutritional supplementation.

  1. Fertility is a sensitive subject for a reason and there are support groups. Fertility and therapeutic counselling is also available for couples trying to conceive naturally. These are also there for individuals and couples using assisted fertility methods.

15 Fertility Rate Facts To Know Now

Susannah understands that when a couple hears a diagnosis of  ‘unexplained infertility’ it’s incredibly frustrating. When natural conception or assisted reproductive fertility treatment haven’t been successful, it’s difficult to hear. The most common assisted fertility treatment is IVF.  We put together 15 fertility rate facts to know now because you want to understand what the next steps are. You want to move forward from this, when ready. You should be able to discuss these steps and come to a decision together.


Nutrition impacts 80% of your modern lifestyle. This impacts every single factor affecting fertility. This goes for both men and women. If you  take ownership of your health you can make sure that the right changes impact you and your partner for the best.


 


Safe, clinical, practical and effective.


Call  020 7060 3181