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Posts Tagged ‘metabolic syndrome’

Story of health

Tired all the time? Is it chronic fatigue syndrome? Insomnia, stress, susceptibility to back pain, stubborn fat, recurring infections like thrushskin conditions – these are all commonly seen by Susannah here. It’s not coincidence. We’re getting sicker and fatter – as a nation but also, our health concerns keep coming back. Why?
Currently, we go to the GP. Everything’s “within normal range” we’re told. But they’ll keep an eye on it. Then it’s already happening. We’re on metformin. Statins. We’re on drugs for life.

Modern medicine

Modern medicine

A transformation in healthcare is underway. We’re transitioning from the science and art of treating disease to the science of health and lifestyle healthcare. Standard GP tests don’t offer any insight into our health. They only test for markers that indicate a specific disease or absence thereof.

Story of health

Reference ranges are based on a severely unhealthy population. These ranges only indicate the levels at which we HAVE the disease or the illness. Rather, at Susannah Makram Clinics we’re looking at what’s OUR basic requirement for optimum health.

You see, we might know when we’ve high cholesterol at the moment we need statins or lipid lowering drugs. But what if there was more to this story? What if we have metabolic syndrome. Does it matter? At Susannah Makram Clinics we believe it does. Why? We’re talking about a whole other treatment in that case.

Lifestyle medicine

Lifestyle medicine

Our modern lifestyle may highlight the very need for this transformation, this change. we’re assessing the state of health of our body to see

i) The interactions between systems of our body
ii) How the patterns of these these interaction influence our health

We analyse our functional test results in this way. So we can give you our special formula:
EAT DRINK TAKE MAKE In The Four Phases.

Functional Blood Chemistry Analysis (FBCA)

Blood Chemistry and CBC Analysis – Clinical Laboratory Testing from a Functional Perspective, is currently used as a teaching tool in medical schools and institutes of higher learning in the US, Canada, Australia and New Zealand, and is the go-to blood chemistry reference manual on the desks and in the clinics of thousands of physicians and healthcare practitioners worldwide.

Pattern analysis of blood chemistry can effectively identify physiological imbalances and nutritional deficiencies by viewing and understanding the complex relationships that exist among blood chemistry factors.

Why blood and who takes it? Blood testing is a medically accepted, proven and a reliable assessment procedure providing a wealth of information on the health and status of our patients. At Susannah Makram Clinics we arrange it so you can have your blood sample drawn at the location you choose. But there is one requirement. The centre must have a centrifuge. This is a device used to spin the blood sample.

Story to health

Story of health

Blood Reference Guide – Clinical Conditions

Blood Chemistry and CBC Analysis – Clinical Laboratory Testing from a Functional Perspective helps thousands of practitioners worldwide. Clinical knowledge cannot be replaced but use of FBCA can help you in your day-to-day practice. Do you want to know more about Functional Blood Chemistry Analysis? Contact us.

Answers before drugs

Imagine having answers about eczema or psoriasis. Knowing the triggers or why you have it in the first place. Knowing why stubborn belly fat remains – even after slogging it out in the gym. What about finding small changes we can make to boost our performance, nip excess belly fat in the bud – before it severely affects our health. A way to successfully sleep at night, healthy weight loss, fat burning, get your energy back. A way to look younger, have clear skin, perform, live, grow.

Better health with drugs

At Susannah Makram Clinics we work with the medical community. What can we  achieve after we’re on the slippery slope of necessary pharmaceutical intervention? Well, it’s hard to say exactly. But if we can help manage symptoms to improve function, mobility, energy levels, we find how we do this at your consultation. We can make every day count and better still, pains and aches that persist, can be manageable. We’re here to help manage chronic disease, not cure it. We’re here to improve health, quality of life i.e. function. 

Glutathione deficiency symptoms

Antioxidant

Glutathione – is this the secret to eternal youth? Well it is the secret #1 antioxidantGlutathione is immune system maestro – glutathione – GLUTATHIONE (pronounced “gloota-thigh-own”). It’s the anti ageing secret we haven’t heard of.

Yet. SKIN –  A 1982 study looked at 61 healthy subjects and 506 patients with various skin disorders. Lowered glutathione levels were observed in patients with psoriasis, eczema / atopic dermatitis, vasculitis, mycosis fungoides and dermatitis herpetiformis. Still asking what’s so important about antioxidants any way?

Glutathione (GSH) is one of the most critical molecules of the entire body. As the most important intracellular antioxidant, GSH regulates all other antioxidants while helping to prevent damage from reactive oxygen species, such as free radicals and peroxides. Read on to find out why…

Glutathione is a very simple molecule. It’s produced naturally all the time in your body. It’s a combination of three simple building blocks of protein or amino acids — cysteine, glycine and glutamine.

Glutathione

Glutathione

Glutathione

The secret of its power lies in the sulfur (SH) chemical groups it contains. Sulfur is a sticky, smelly molecule that acts like fly paper. So all the bad things in the body stick onto it. That includes free radicals and toxins like mercury and other heavy metals. Normally glutathione is recycled in the body — except when the toxic load becomes too great.

Glutathione – Cont’d

The body naturally produces glutathione. Glutathione is the most potent antioxidant, which also regulates all other antioxidants. But environmental and dietary toxins, emotional stressors and various health conditions can deplete glutathione levels. This will impair our immunity. It can also leave our body vulnerable to inflammation or illness. It may reduce natural cellular repair processes altogether.


We can test the genes involved in glutathione metabolism when it’s indicated in delivering the right treatment at Susannah Makram Clinics.  These are the genes involved in producing enzymes that allow the body to create and recycle glutathione in the body. These genes have many names, such as GSTM1, GSTP1 and more.


These genes impaired in some people for a variety of important reasons. It doesn’t help that we evolved before 80,000 toxic industrial chemicals existed in our modern day environment. As Knightsbridge and Harley Street nutrition expert I can’t tell you how much of this I see. It doesn’t help either that we evolved before electromagnetic radiation was everywhere. Before we polluted our skies, lakes, rivers, oceans and teeth with mercury and lead. Almost of half of the population now has a limited capacity to get rid of toxins. These people are missing GSTM1 function.

Gluatathione deficiency symptoms

Glutathione deficiency symptoms

Glutathione deficiency symptoms

Stress and Illness

We become susceptible to unrestrained cell disintegration from oxidative stress, free radicals, infections and cancer. Our liver gets overloaded and damaged, making it unable to do its job of detoxification.

Mental and Physical dysfunction

Research has shown that raised glutathione levels decrease muscle damage. If that wasn’t amazing in itself, raised glutathione levels also reduce recovery time, increase strength and endurance. Raised levels of glutathione also shift metabolism from production of fat to muscle development.

TO SUMMARISE –> Glutathione is critical for immune function and controlling inflammation. It’s the master detoxifier and the body’s main antioxidant. Glutathione protects our cells and making our energy metabolism run well.

ACG Glutathione Extra Strength from Results RNA also contains alpha lipoic acid, milk thistle and more. This is all designed to help naturally support GSH absorption and action.

Cholesterol – Debunking Myths

High fat diet cholesterol

HIGH FAT DIET – What’s this? HIGH CHOLESTEROL DIET works by lowering intake of dietary fat – true or false? High fat diets like paleo or bullet proof, low carb or Atkins cause cholesterol problems, correct? Not true, entirely. One of the biggest cholesterol myths out there has to do with dietary fat. READ ON AS WE BREAK THIS DOWN…Susannah debunks cholesterol myths.
✗ Trans fats or hydrogenated fats and saturated fats promote abnormal cholesterol, whereas…

✔ Omega-3 fats and monounsaturated fats actually improve the type and quantity of the cholesterol your body produces.          

LOW fat diet

LOW fat diet

Cholesterol Level – What is cholesterol?

Cholesterol is a fatty substance produced by the liver. The body uses it to help build your cell membranes, the covering of your nerve sheaths, and much of your brain. It’s a key building block for our hormone production: testosterone, oestrogen, progesterone and cortisol. 

✔ The biggest source of abnormal cholesterol is sugar and specifically High Fructose Corn Syrup.

✗ “Corn sugar” or High Fructose Corn Syrup HFCS and cane sugar are essentially the same


HFCS and cane sugar are NOT biochemically identical or processed the same way by the body.     

“The digestion, absorption, and metabolism of fructose differ from those of glucose. Hepatic metabolism of fructose favors de novo lipogenesis (production of fat in the liver). In addition, unlike glucose, fructose does not stimulate insulin secretion or enhance leptin production. Because insulin and leptin act as key afferent signals in the regulation of food intake and body weight (to control appetite), this suggests that dietary fructose may contribute to increased energy intake and weight gain. Furthermore, calorically sweetened beverages may enhance caloric over-consumption.” (i)


✔ HFCS contains toxic levels of mercury because of chlor-alkali products used in its manufacturing.

✔ Consumption of high fructose corn syrup, which is present in soft drinks or fizzy drinks, many juices, and most processed foods, is the primary nutritional cause of most of the cholesterol issues

Harmony & Sensuality. Romantic Blond Female in Black Dress resting in Armchair. Satisfaction

HIGH CHOLESTEROL

✔  Total cholesterol is not as critical as the following:

  • Your levels of HDL “good” cholesterol vs. LDL “bad” cholesterol
  • Your triglyceride levels
  • Your ratio of triglycerides to HDL
  • Your ratio of total cholesterol to HDL

✗ Your lipid profile as often requested by your GP will indicate levels of LDL – keeping this in check is enough to keep you off statins e.g. Lipitor

✗ It is not important to know that there are different sizes of cholesterol particles.

✔ There are different sizes of cholesterol particles. There are small and large particles of LDL, HDL, and triglycerides. The most dangerous are the small, dense particles that act like tiny bullets, easily penetrating your arteries. Large, fluffy cholesterol particles are practically harmless–even if your total cholesterol is high. They bounce off the arteries like beach balls and cause no harm.

✔ The risk of arterial plaque is the more accurate heart attack risk assessment

✔ CVD – as with all disease states – can be prevented or targeted treatment can be administered only by determining the cause; examination and assessment of overall health, the interaction of your genes, lifestyle, and environment that ultimately determines your risks — and the outcome of your life. We practice this functional approach here


Rancid or oxidised cholesterol results from oxidative stress and free radicals, which trigger a vicious cycle of inflammation and fat or plaque deposition under the artery walls.        [tweetthis]Rancid or oxidised #cholesterol results from oxidative stress and free radicals[/tweetthis]    That is the real danger: When small dense LDL particles are oxidised they become dangerous and start the build up of plaque or cholesterol deposits in your arteries.


✔ What is the point in discovering that this is the case by targeted testing if there is no solution? The solution is your Naturopathic Portfolio: Safe, Clinical, Practical, Effective management of this cause or the causes of this type of inflammation. If oxidative stress is a factor then the right antioxidant therapy will play a part – at the right time – in the right way, that is bioavailable and therefore taken up and used by your body to eradicate this issue.

✗  By the time there is inflammation it is too late 

✔ As discussed, cardiovascular illness results when key bodily functions go awry, causing inflammation, imbalances in blood sugar and insulin and oxidative stress

✔ We use the science of nutrigenomics, or how food acts as information. This can be used to stall or totally prevent some predisposed disease risks by turning on the right gene messages with our diet and lifestyle choices. That means some of the factors that unbalance bodily health are under your control, or could be given the right test and therefore, treatment.genetic-makeup

✗ Diet, nutritional status, stress and activity levels cannot be assessed accurately.

✔ The right tests can reveal problems with a person’s blood sugar and insulin, inflammation level, level of folic acid, clotting factors, hormones, and other bodily systems that affect your risk of cardiovascular disease.


What do we mean by inflammation and how do we reduce it?

We test for inflammation  here Cardio C-reactive protein. This is a marker of inflammation in the body that is essential to understand in the context of overall risk. Your C-reactive protein level should be less than 1.

Inflammation can arise from poor diet (too much sugar and trans and saturated fats), a sedentary lifestyle, stress, autoimmune disease, food allergies, food intolerance, hidden infections such as gum disease, and even toxins such as mercury. All of these causal factors need to be considered anytime there is inflammation. We conduct clinical consultation and examinations to evaluate these in order to target your treatment effectively.
Safe, Clinical, Practical, Effective 


✗  Cholesterol levels are the best indicator to predict Coronary Heart Disease

✔A major study done at Harvard found that people with high levels of a marker called C-reactive protein (CRP) had higher risks of heart disease than people with high cholesterol. Normal cholesterol levels were NOT protective to those with high CRP. The risks were greatest for those with high levels of both CRP and cholesterol. (ii)

✔ Metabolic Syndrome or Insulin Resistance can be tested and treated to manage pre-diabetes (typically in middle age and in PCOS patients) before full blown DM2 takes over. This can prevent or slowly reverse reliance on blood-sugar regulating medication, commonly Metformin 

✔ The side effects of statins have been called to question recently in a research study by the Cleveland Clinic. Problems including muscle pain and weakness have been called to question in this recent study. Statin intolerance is real. (iii)


Elevated levels of a substance called homocysteine (which is related to your body’s levels of folic acid and vitamins B6 and B12) appears to correlate to cardiovascular illness. We measure Homocysteine. Your homocysteine measures your folate status and should be between 6 and 8. Where problematic levels occur, they can be easily addressed by adequate folic acid intake, along with vitamins B6 and B12.


(i) Bray, G.A., Nielsen, S.J., and B.M. Popkin. 2004. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 79(4):537-43. Review.

(ii) Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008 Nov 20;359(21):2195-207.

(iii) Steven E. Nissen, MD et al Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance. JAMA. Published online April 03, 2016. doi:10.1001/jama.2016.3608

Health Risks Of Obesity

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What is Obesity

In an adult the diagnosis of obesity is most commonly made using BMI levels. These provide a measure to be viewed in parallel with the health risks of obesity. BMI is calculated as weight in kilograms (kg) divided by height in metres squared (m2). Ideal BMI is 18.5 to 24.9 kg/m2. The following classification is advised by NICE:

  • A BMI of 25-29.9 kg/m2 is overweight.
  • A BMI of 30-34.9 kg/m2 is obese (Grade I).
  • A BMI of 35-39.9 kg/m2 is obese (Grade II).
  • A BMI of ≥40 kg/m2 is obese (Grade III) or morbidly obese, meaning that weight is a real and imminent threat to health.

Waist circumference in men:

  • <94 cm is defined as low risk.
  • 94 to 102 cm is defined as high risk.
  • >102 cm is defined as very high risk.

Waist circumference in women:

  • <80 cm is defined as low risk.
  • 80 to 88 cm is defined as high risk.
  • >88cm is defined as high risk.

Waist circumference is used in combination with BMI to assess your health risk of obesity       [tweetthis]Waist circumference is used in combination with #BMI to assess #health risk of #obesity[/tweetthis]

Obesity and Genetics

Obesity is the result of a complex pathophysiological pathway involving many factors that control adipose tissue metabolism. Cytokines, free fatty acids and insulin all play a part and genetic defects are likely to have a significant effect on the fine balance of this process. Nam H, Ferguson BS, Stephens JM, et al; Impact of obesity on IL-12 family gene expression  in insulin responsive tissues. Biochim Biophys Acta. 2013 Jan;1832(1):11-9. 

Obesity and Health

Obesity and Health

KRS2 is one gene that has recently been identified as being implicated in obesity and metabolic rate. DNA sequencing in over 2,000 obese individuals identified multiple mutations of the KRS2 gene, and mutation carriers exhibited severe insulin resistance and a reduced metabolic rate. It may be that modulation of KSR2-mediated effects may have the potential to have therapeutic implications for obesity.
Pearce LR, Atanassova N, Banton MC, et al; KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell. 2013 Nov 7;155(4):765-77.

Find Out More…

Living with morbid obesity means living at risk for serious health conditions for both men and women combined where applicable. For example, the health risks of obesity are – in terms of the following diseases:-

Type 2 Diabetes
Hypertension
Myocardial Infarction
Colon Cancer
Angina Pectoris
Gall Bladder Disease
Ovarian cancer
Osteoarthritis
Stroke

Obesity and Health

Obesity increases the risk of breast cancer. It also increases the risk of carcinoma of the endometrium. Polycystic Ovary Syndrome PCOS is usually associated with obesity, as is stress incontinence. Obesity impairs fertility in males and females. Obesity increases the risk of fatty liver, along with other features of the metabolic syndrome. Obesity is an important risk factor in the development of chronic respiratory disorders such as COPD, asthma, obesity hypoventilation syndrome, obstructive sleep apnoea. If the person develops a surgical condition, diagnosis is more difficult and almost every postoperative complication is more frequent, including deep vein thrombosis DVT chest infection and wound dehiscence. Not only is osteoarthritis  more common but treatments such as total hip replacements are more likely to be problematical in obesity.


Safe, clinical, practical and effective.


Call  020 7060 3181