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When IVF Fails

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Infertility Treatment

INFERTILITY CARE PATHWAYS depend on 1) WHEN infertility diagnosis made (2) age (3) your partner’s age (4) many personal preferences. When IVF fails we reassess these causes. At Susannah Makram Clinics we view infertility as a complete care pathway. That this may be supported by our individual body wellness is where we come in.

When IVF Fails

When IVF fails your decision to go ahead with the same treatment for infertility is usually put into question. This is a natural reaction to have.

In vitro fertilisation (IVF) is the most common ART technique. When IVF fails, the decision to continue with another IVF cycle, at the earliest possible time, is not one to take lightly. Assisted reproductive technology (ART) is any fertility treatment in which the egg and sperm are handled.
IVF involves stimulating and retrieving multiple mature eggs from a woman, fertilising them with a man’s sperm in a dish in a lab, and implanting the embryos in the uterus three to five days after fertilisation.

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When IVF Fails

IVF Success Rates

IVF-conceived babies now account for 2% all babies born in the UK.      [tweetthis]IVF-conceived babies now account for 2% all babies born in the UK[/tweetthis]

The success rate of ART is lower after age 35. This is according to new figures on infertility treatment us and outcomes. these figures are released annually by the Human Fertilisation and Embryology Authority (HFEA).

When choosing a fertility clinic carrying out IVF treatment The HFEA presents success rates for every licensed clinic.

Some women need just one or two therapies to restore fertility. It is possible that several different types of treatment may be needed before you are able to conceive.


GENETIC and CHROMOSOMAL issues causing FAILURE OF IMPLANTATION in IVF – The high rate of chromosomal abnormalities in human embryos.

  • As women age, the incidence of chromosomal abnormalities in mature eggs increases significantly. Studies have shown that starting in early 30s, the rate of chromosomal abnormalities in human eggs (and therefore in human embryos) starts to increase significantly.
  • The rate continues to increase with advancing female age. By mid-40s a very high percentage of human embryos are chromosomally abnormal (over 75%).
  • It’s believed that this is mainly due to problems with the spindle apparatus in the egg nucleus. The spindle is involved with properly lining up and segregating the chromosomes as the egg matures at the time of ovulation.
  • Older eggs have an inefficient spindle apparatus that does not line up the chromosome pairs properly. “Mistakes” are made when splitting pairs of chromosomes. This leads to eggs that don’t have the proper balance of 23 chromosomes – and will result in a chromosomally abnormal embryo if fertilised.
  • It has been shown that about 1% to 2% of human sperm are chromosomally abnormal on average – as compared to about 20% to 90% of human eggs (depending on female age).
    lab

    When IVF Fails

PGS – preimplantation genetic screening can be done on embryos prior to transfer to evaluate chromosomal competence.

Other “genetic causes” of implantation failure

  • Implantation failure is probably caused by other genetic mutations sometimes. With a perfectly normal “karyotype” or chromosome complement.
  • There are tens of thousands of genes in the human genome. A lot of places where something can go wrong.
  • With time there will be genes discovered that are crucial for efficient embryo implantation. These will be both on the embryo side and on the uterine side. Perhaps they will involve the immune system as well.

INFERTILITY treatment involves commitment that is significantly financial, physical, psychological and time consuming. Male infertility treatment for general sexual problems or lack of healthy sperm at Susannah Makram Clinics use advanced male fertility diagnostics to outline effective treatment protocols for couple to choose from. Tests identify and support improvement for (normal sperm count and) poor sperm quality.

Your Naturopathic Portfolio to improve sperm quality at Susannah Makram Clinics supports ICSI if used in an IVF cycle as described.
FIND OUT MORE ABOUT FERTILITY TREATMENT ROUTES AND HOW SUPPORTING LIFESTYLE CHANGES CAN HELP COUPLES TODAY.

Female fertility continued 

Hungry All The Time

Why Hungry All The Time

HUNGRY all the time? After a meal do you FEEL FULL or STILL HUNGRY.. moments later? Trying to lose weight?Following a strict diet? May be DOING A DETOX or cleanse? The weight is not shifting, however.

Being on a healthy eating plan may be a radical change or too many changes all at once. Sometimes we’re pretty good at sticking to this. But when stubborn fat like belly fat sticks, we lose our motivation. Excess “water weight” or feeling bloated  is exceptionally uncomfortable. It also affects our posture and can strain muscles in our upper back.

Here are some reasons why and how you can change this pattern and find your successful weight loss solution.

Hungry All The Time

  1. You did not include enough fibre in your meal – gluten free diets that are prescribed for individuals with gluten intolerance or allergies need to make sure their uptake of dietary fibre (soluble, insoluble) is adequate and supplement accordingly.
    Hungry All The Time

    Hungry All The Time

  2. BPA – BPA is the lining often found in cans that prevent corrosion. BPA is also found in some plastics, like water bottles and other food packaging materials. If you are obese and leptin-resistant, your body is not getting a clear message from the leptin that you are full; you feel hungry because your body still thinks you are starving so your chances of experiency true satiety are merely reduced. So if you are tackling obesity by trying to lose weight, the chances are you might be leptin resistant and as BPA increases leptin levels in the body, and leptin is meant to decrease hunger, this tactic will not work for you.
  3. LEPTIN RESISTANCE  – Do you have a problem where you HAVE TO EAT immediately BEFORE BED to fall asleep — even if you’re not hungry? Do you  wake up in the middle of the night and have to eat again to fall back to sleep? these may be signs of leptin resistance which can be treated directly Leptin, adiponectin, and resistin are produced by the adipose tissue. The protein leptin, a satiety hormone, regulates appetite and energy balance of the body. Leptin resistance is a hallmark of obesity, but its etiology is unknown, and its clinical measurement is elusive.
  4. Your genes – DNA testing for weight loss is a science that makes the way your body reaches its healthy weight loss goal unique. You are as unique as your DNA. Safe, Clinical, Practical, Effective = your weight loss Naturopathic Portfolio  Fat metabolism, obesity and satiety are governed by the genetic influence of APOA2 -265 T>Cgenetic-makeup
  5. You are not eating the right balance of fat, protein and carbohydrate based on your personal weight magnet genetic test report
  6. 90% of human illness can be traced to an unhealthy gut. The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study. If your dietary intake is feeding the “bad bacteria” in your gut, this physiological process may be key to putting a halt on your unsuccessful weight loss that has so far been frustrating.
  7. Nutrients from your food or diet are not being fully absorbed. Side effects of malabsorption are that heavy feeling you get in your gut. Bloating, fatigue and ultimately a reduction in digestive enzyme activity are not a recipe for burning fat. Fat burning may be your healthy weight loss goal. Ultimately, this inability to break down food  can lead to an accumulation of stubborn unwanted fat.

What affects fertility?

Total fertility rate

Nutrition for fertility and pregnancy is included in our functional approach to male and female fertility nutrition. We treat with care for the individual and also the couple, at Susannah Makram Clinics

What 5 Factors affect fertility?

Total fertility rate – What affects fertility?

1. Poor nutrition is the biggest factor that affects fertility. Nutrition during pregnancy is seen by measurements taken of a growing a healthy baby. 4 to 6 months before trying to conceive couples are building the foundation. A woman’s body is ready to provide a nourishing environment for growing a baby.

The 9 months of pregnancy are now considered by a lot of researchers to be the most consequential period of our lives. Before we are even born, this time is most important in determining our health for the rest of our life.   [tweetthis]Before we’re even born, this time is most important in determining lifetime #health [/tweetthis]

Babies that are born at a low birth weight, which is primarily determined by maternal nutrition, have a significantly higher risk for diseases. These disease include heart disease, diabetes, hypertension, kidney disease. Later in life the risk for these diseases rises independently of lifestyle risk factors.

For healthy sperm

Obesity in men affects fertility because accumulation of fat in the thighs increases the temperature of the scrotum. This in turn adversely impacts sperm quality. Infertile men have lower concentrations of DHA and EPA in their sperm. They are unlikely to be eating eating enough of the long chain omega-3 fats.

2. This is followed closely by stress

Moura-Ramos, M., Gameiro, S., Canavarro, M., Soares, I. and Santos, T. (2012). The indirect effect of contextual factors on the emotional distress of infertile couplesPsychology and Health, 27(5), 533-549. (10.1080/08870446.2011.598231
Barnea ER, Tal J. Stress-related reproductive failure. J In Vitro Fert Embryo Transf. 1991 Feb;8(1):15–23.

50% of infertility is caused by male factors. Oxidative stress is caused primary by excess intake of industrial seed oils, stress and lack of physical activity can damage sperm quality.

The biggest factor keeping women from getting pregnant is the modern lifestyle and it is a big problem because already 1 in 7 women have trouble conceiving. A study out of the UK that suggested that this number could rise to 1 in 3 by 2020

What affects fertility?

What affects fertility?

What affects fertility? Other Factors:

3.  Environmental toxins – there are a lot of toxins that end up being endocrine disrupters. These throw the hormones out of whack and that makes it difficult for women to get pregnant.

4.  Medications like birth control – A medical term has been coined Post Birth Control Syndrome  or ‘post-pill amenorrhea’

In some women, it may take some time for their menstrual cycle (and subsequently their fertility) to return to normal when they stop taking birth control pills. The main symptom is a rather obvious one. A woman is unable to conceive even after she has discontinued the use of the birth control pill. Generally speaking, your period should resume within three months. If you have a history of irregular periods and took the pill to regulate your cycle, you may not have a period for many months after you stop taking the pill. If you do not have a period within 6 months, you should see your doctor to determine the cause.

What affects fertility?

5. Medications that affect hormones, metabolism, and synthesis i.e. modern lifestyle  

50% of infertility is caused by male factors. Men should be testosterone dominant not oestrogen dominant and oestrogen dominance in men leads to hypogonadism and infertility. The lower the sperm count and the poorer the sperm quality, the longer it will take to get pregnant. The omega6/omega3 balance is probably one of the biggest factors in male infertility.

What is fertility?

What is fertility?

Side effects of long-term NSAID usage. Long term use or a high dosage of NSAIDs, such as ibuprofen or aspirin, can make it more difficult for you to conceive. Medicines used for chemotherapy (a treatment for cancer) can sometimes cause ovarian failure. This means your ovaries will no longer be able to function properly. Ovarian failure can be permanent.

Side effects of spironolactone. Fertility should recover around two months after you stop taking spironolactone for fluid retention.

Side effects of Neuroleptic medicines. Neuroleptic medicines are antipsychotic medicines often used to treat psychosis. They can sometimes cause missed periods or infertility.

Food Intolerance Test UK

Food Intolerance Test

Food sensitivity or food intolerance: where, when, how? Common food intolerances to gluten; wheat intolerance; dairy; yeast; alcohol; histamine… Food sensitivity or food intolerance are hard to identify ourselves. HERE’S WHY…


FOOD INTOLERANCE reactions to food occur UP TO 72 HOURS AFTER EATING.


Clients for functional nutrition in London may have lots of test results to hand. Every one of them has produced VARYING DATA. How unhelpful is that? We understand your frustration at Susannah Makram Clinics.

 

Allergy or Intolerance

Only about 2% of the adult population are affected. A FOOD ALLERGY is a SWIFT RESPONSE by the body’s immune system to a specific food. Reactions to food allergy are immediate by raised levels (2 hours or less)….

 food intolerance symptoms

food intolerance symptoms

Keep reading for the symptoms of food intolerance. So, they’re difficult to self diagnose. Also, food intolerance test results aren’t helpful if we don’t:

(i)    Know where the triggers can be found in our day to day diet
(ii)   How long we need to avoid the foods
(iii)  Know why we are suddenly reacting to food we ate without any problems whole our entire lives. Does this mean we have to              avoid all these food completely now forever?

That’s not all…

A recent study has shown that those who eliminated trigger foods based on food-specific IgG test results had reductions in weight, BMI body mass index, waist and hip circumference and improvements in all indicators of quality of life that were measured. Quality of life indicators include physical and emotional wellbeing, mental health, social life, pain levels and vitality.

Food Intolerance Symptoms

Food intolerance symptoms — bloating; eczema; sinus problems, lead us to ask: is the food we’re eating making us ill?      [tweetthis hidden_hashtags=”#foodintolerance”]Do you think that the foods you are eating are making you ill?[/tweetthis]
Genuine food allergy is relatively rare. Food intolerance symptoms like migraine, tiredness, bloating affect up to 45% of us. Why? 

Many Symptoms can be linked to food intolerance and they include…

Abdominal pain | Aches and pain | Acne | Bloating | Constipation | Chronic Fatigue Syndrome | Diarrhoea | Atopic Dermatitis or Eczema | Fatigue | Irritable Bowel Syndrome | Itching | Fluid Retention | Headache | Hyperactivity | Migraine | Nausea | Rashes | Rhinitis | Sinusitis | Stomach Cramps | Tension | Tiredness | Urticaria or Hives | Weight Loss/ Weight Gain


An Independent Customer Survey conducted by Allergy UK (2007), carried out on 5,286 people – the results were then divided into patient groups and the findings are summarised here:

Main Medical Condition Reported                  % of People Who Reported Moderate to High Benefit

Gastro-Intestinal  e.g. IBS, Bloating etc                                          80%
Respiratory  e.g. Asthma, Breathing Difficulties, Rhinitis           72%
Neurological  e.g. Migraine, Headaches                                        78%
Dermatological  e.g. Eczema, Acne, Psoriasis                                 76%
Musculo-Skeletal  e.g. Arthritis, Rheumatism                                64%
Psychological  e.g. Depression, ADHD, Panic Attacks                  81%
Others  e.g. Lethargy, General Feeling of Malaise                          79%


 

Food Intolerance Symptoms

Food Intolerance Symptoms

There are no international standards available for tests that measure food-specific IgG antibodies. The only way that a particular food specific IgG test can be shown to be valid is by carrying out clinical trials.

Benefits of Food Intolerance Testing at Susannah Makram Clinics:

| Hospital standard laboratory tests

| Utilising laboratories with over 30 years’ experience in the field of diagnostic testing

| Four tests available at Susannah Makram Clinics

| Fast turnaround of results

| Comprehensive results reported as individual food tested by name labelled as having: – Reaction, Borderline, No Reaction and  applied to be Safe, Clinical, Practical, Effective for you and your needs inside your Naturopathic Portfolio
If you’re overwhelmed by the idea of making drastic changes you’re not alone. Many tests produce false positives. Take the right test but not without seeking advice to unlock your potential – your Body Youth Code.

SpermComet Results Guide

DNA in sperm

Paint a clearer fertility profile picture with the SpermComet test. HOW? Measuring sperm DNA damage in individual sperm using the most sensitive test.       [tweetthis]SpermComet: most sensitive test that can measure sperm DNA damage in individual sperm [/tweetthis]
We’re probably all familiar with with the term SPERM COUNT that deals with the quantity of sperm. However, what most of us know less about is SPERM QUALITY.


For couples trying for a baby, when it comes to sperm quality, conventional semen analysis tells us little. One in Four couples in the Uk have difficulty starting a family. The Sperm DNA test may help guide couples. Don’t wast time. Find out if it’s worthwhile taking this test – the most sensitive of its kind – contact us 0207-060-3181


If you’ve already been trying for a baby, or even just starting to think about it, measuring sperm DNA damage in individual sperm paints a clearer fertility profile picture:  [tweetthis]Trying for a baby, or starting to think about it? See your fertility profile clearly[/tweetthis]


<25% Damage = Sperm DNA damage is not the major cause of infertility Damage

>25% Damage = Sperm DNA damage is a cause of infertility

-> Refer to fertility clinic

25-49% Damage = Sperm DNA damage is a cause of infertility

-> Lifestyle Changes + Antioxidants
-> IVF may be the best option

>50% Sperm DNA Damage

-> Lifestyle Changes + Antioxidants
-> ICSI may be the best option

>50% Sperm DNA Damage & Failed ICSI

-> Lifestyle Changes + Antioxidants
-> Testicular Biopsy may be the best option
-> Alternatively ICSI with donor sperm may be considered


ICSI – Intra-cytoplasmic Sperm Injection – is the most successful form of treatment for men who are infertile and is used in nearly half of all IVF treatments (HFEA 2010). ICSI only requires one sperm, which is injected directly into the egg. The fertilised egg (embryo) is then transferred to your uterus (womb) (HFEA 2009a)


 One in six couples has difficulty having a baby: in 40 per cent of these cases, the difficulty is associated with the man.


Susannah2

When it comes to sperm, not talking about it means many couples trying for a baby may be missing out on information that could improve their chances… information that could help reduce the loss of valuable time and financial costs and – not least – the emotional heartache that can be hardest of all.

When IVF fails it’s a frustrating situation for couples and their fertility doctors. Sperm DNA Fragmentation Testing results can help be a guide for couples.

Hair loss treatment

Hair loss treatment

Hair loss treatment after pregnancy, with ageing, medical treatments depends on hair loss cause as well as how to manage thinning hair. We’ll cover these here. The areas we won’t will be here  so follow for stories on the best shampoo, oils, conditioner for thinning hair. We’ll break down treatments that work, don’t work for hair damage.

Best hair treatment

Most people normally shed 50 to 100 hairs a day. This does not usually cause noticeable thinning of scalp hair because new hair is growing in at the same time. Shedding significantly >50-100 hairs daily=person has excessive hair shedding.

Hair shedding often stops on its own. When the body sheds significantly more hairs every day, a person has excessive hair shedding. The medical term for this condition is telogen effluvium.

Excessive hair shedding is common in people who have experienced one the following stressors:

  • Stopped taking birth-control pills
  • Recovering from an illness, especially if had a high fever
  • Undergone an operation
  • Had high fever
  • Experiencing lots of stress (Caring for a loved one who is sick, going through a divorce, losing a job)
  • Given birth
  • Lost 20 pounds or more
    Hair loss treatment

    Hair loss treatment

Where did your healthy lustrous locks go? Hair loss differs from hair thinning. Hair loss occurs when the normal cycle of hair growth and shedding is disrupted or when the hair follicle is destroyed and replaced with scar tissue. We can categorise the reasons for hair loss as being related to one or more of the following four factors:

How to stop hair loss

Because of the hormone imbalances associated with PCOS (high insulin, high androgens or hyperandrogenism, low progesterone, and imbalanced ratio of 0estrogen to progesterone), women can suffer from Female Pattern Hair Loss. High levels of testosterone reduces the rejuvenation of the hair follicles in the scalp alone. 

Susannah2Hair loss occurs when something stops the hair from growing. The medical term for this condition is anagen effluvium. The most common causes of hair loss in detail include:

  • Hereditary hair loss
  • Immune system overreacts
  • Some drugs and treatments (e.g. chemotherapy)
  • Hairstyles that pull on the hair
  • Harsh hair care products
  • Compulsion to pull out one’s hair

Hair loss treatment

Identifying the cause or causes of your hair loss is key in our Functional Medicine approach to the Naturopathic Portfolio for Hair Health.  Treating the known as opposed to treating the unknown (symptomatically) is what makes your Naturopathic Portfolio for Hair Health Safe, Clinical, Practical, Effective.

If you want to heal your skin you need to heal your gut – and that goes for the scalp as well.

Pain and Gut Inflammation

As a London Osteopath offering a complete care pathway for low back pain and musculoskeletal strains and sprains we do need to include the element of nutrition for total body wellness. Chronic pain change our bodies internal environment

  1. Pain and gut inflammation – what is pain? Defining it  & Redefining it  – A gold standard method for measuring Pain does not exist in practice. There is no universally recognised unit that can, in the present day, be called into existence.
  2. Background – History of Pain – Pain Discovery – Measuring Pain – In the 1940s, a group of doctors at the University of Cornell set out to create a unit of pain intensity. Using the “dol” as a unit, the physicians created a 21-point quantitative scale. Their hot pursuit of knowledge was perhaps reflected in the means by which they gathered relevant data. They tested pain reactions on medical students and women in labor between contractions. Also, they did this by burning their subjects. Understandably, such methods were deemed controversial and “dol” never quite caught on as a unit of pain measurement. Subsequent attempts at method justification, for the sole purpose of recruiting a unit measurement of pain, did not receive the required research grants. It would seem that inflicting pain artificially, or allowing for the natural occurrence of this experience, could not morally accommodate for a study of pain that would be of significant future benefit to the suffering individual.

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Consequently, the National Institute of Nursing Research reference that “Pain remains a uniquely personal experience that cannot be measured objectively.”        [tweetthis]#Pain remains a uniquely personal experience that cannot be measured objectively[/tweetthis]


  1. Two definitive categories should be used to inform the pain medicine practice of all health care professionals: Acute Pain – This can be defined as pain that lasts less than 6 weeks, or pain that is directly related to tissue damage. The pain that is experienced from a paper cut or from standing on a tack is acute pain. Pain that is felt after an operation is acute pain; it is severe, but we expect it to go away. Chronic Pain – This can be defined as pain that lasts longer than 3 months. There are at least two different types of chronic pain problems — pain that has an identifiable cause, (an injury), and pain with no longer an identifiable cause (the injury has healed). Most of chronic pain is of musculoskeletal origin.
  2.  Other terms used to describe or define pain include: Neuropathic Pain – Mechanical
    Inflammatory – Chemical (Metabolic) – Somatic – Visceral Referred & Ischaemic Pain
  3. Clinically, the most common tests to diagnose inflammation include measuring erythrocyte sedimentation rate (ESR), white blood cell count, and albumin levels (and other biomarkers) These tests are nonspecific; that is, an abnormal result might result from a condition unrelated to inflammation. Such non-specific tests do not account for IBS and SIBO for example.
  4. If you are seeking solutions by way of nutritional therapy, recognising signs and symptoms of gut health and acute, sub-acute and chronic inflammatory process, as well as being able to interpret laboratory reports thus, is unique and invaluable when it comes to getting results for healthy weight loss, unexplained fatigue etc.
  5. The principles of Naturopathy were first used by the Hippocratic School of Medicine in about 400 BC. The Greek philosopher Hippocrates believed in viewing the whole person in regards to finding a cause of disease, and using the laws of nature to induce cure. It was from this original school of thought that Naturopathy takes its principles.


Other Referenced Definitions Of Pain

Pain is what the person says it is, existing when and where the person says it does.” (McCaffery & Beebe, 1999)
Margo McCaffery is a Nurse Consultant who has published widely about pain medicine. What she is saying here is that pain is individual to the patient, the best judge of the intensity of the pain is the patient, and that the patient should be believed. This definition of pain is taught to all nursing and medical students.
The International Association for the Study of Pain (IASP) defined pain as: “An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” (IASP, 1979)
The importance of this definition is that it includes pain that may occur without any recognised stimulus, and it also introduces recognition that pain is influenced by our emotions.
The British Pain Society have a useful glossary of medical terminology, on which pain is defined as:-
“…An emotion experienced in the brain, it is not like touch, taste, sight, smell or hearing. It is categorised into Acute pain – less than twelve weeks duration and Chronic pain – of more than twelve weeks.
Pain can be perceived as a warning of potential damage, but can also be present when no actual harm is being done to the body.”

Bad Gut Health Symptoms

Bacteria in gut

BEST SELLING PRESCRIPTION DRUGS. These drugs are changing our gut bacteria. What does this mean when we’re after good gut healthEVERY YEAR there’s a list of the top selling prescription drugs. (Read on to find out what these are).

Nutrition expert Susannah assesses gut health  our gut health reflects our overall health.

At our London clinics we find patterns in YOUR HEALTH STORY. What does this mean exactly? Gut health and gut bacteria is a topic of overwhelming interest in functional healthcare right now.

WHY DOES THIS MATTER? 

The types of bacteria in our gut are summarised here. Gut bacteria are either growing in number or dying.
Our gut microbiome depends on 1) nutrition 2)lifestyle 3) environment. READ ON for 7 SIGNS we have an UNHEALTHY GUT
Gut bacteria rely on what we’re feeding them. The good bacteria we hear about is the one we try to cultivate. More about good and bad gut bacteria and gut health probiotics can be found here.

The top 25 best selling prescription drugs

The top drugs prescribed to the world include cholesterol-lowering drugs or statins. Also, drugs for chronic pain. Top of the chronic pain list are Humira an anti-inflammatory for arthritis   and oxycontin and vicodin. These tally high for pain relief consistently. Insulin glargine injection for type 1 diabetes, metformin for type 2 diabetes and asthma medications like albuterol also rank in the top ten. Several antacids like omeprazole and other drugs for indigestion always rank high.


Research firm IMS compiles a rolling 12-month history in the US. The pharmaceutical industry publication Genetic Engineering and Biotechnology News (GEN) do as well.

Gut Health

Gut health refers to the function or dysfunction of the gastrointestinal (GI) tract.

How do we maintain gut health? Any impairment of the Gut lining can increase the risk of developing infectious, inflammatory and functional GI diseases. An example of gut lining impairment is leaky gut syndrome.


As well, impairment can increase risk of extra-intestinal diseases, such as immune-mediated and metabolic disorders. GI barrier impairment can increase risk of immune-mediated & metabolic disorders.


 

Bad Gut Health

Bad Gut Health

Less clear, however, is whether GI discomfort in general can also be related to GI barrier functions. In any case, methods of assessing, improving and maintaining gut health -related GI functions are of major interest in preventive medicine. It is worth looking out for your body’s bad gut health symptoms.

A healthy gut

When we feel something’s not quite right, often it’s more than just a gut feeling. As powerful as those are, our precious health calls for understanding and finding solutions. The more we know, the more we can do. Signs of an unhealthy gut are below.

  1. You have a lowered immune response. 70-80% of our immunity to infection and disease is controlled by your gut microbiota.      [tweetthis]70-80% of your immunity to infection and disease is controlled by your gut microbiota[/tweetthis]      Your immune system launches a response, resulting in inflammation. This response might include recent developments of food allergies or food intolerances that you are experiencing later on in life.
    Allergies

    Allergies

  2. You experience unexplained changes in your weight. Bowel and bladder habits are affected. E.g. IBS, digestive issues such as gas and bloating.
  3. You suffer from tiredness that is unexplained. As featured by the Mayo Clinic, studies are connecting bacteria to its effect on energy absorption. “Researchers have identified a difference in the types of bacteria found in a lean person’s gut versus those that live in the gut of someone who is obese. The amount of energy is small, but researchers wonder if over time this could be a factor in weight maintenance.”
  4. You suffer from mood swings, anxiety disorders, depression, poor memory, poor concentration, ADHD or ADD. These may be due to inflammation in the gut. The gut-brain axis explains this.
  5. You have or have had autoimmune disease. Autoimmune diseases examples are alopecia areata, Coeliac disease, RA, MS, vilitgo, Raynauds, SLE, reactive arthritis, Addison’s disease, Psoriasis etc.
  6. You have skin conditions that are recurrent. Typically your skin issues are non responsive to medication. they don’t respond well to medical grade topical solutions and treatments. Or, they are a temporary solution, until the next outbreak. An example is adult acneacne vulgaris or eczema or rosacea
  7. You have diabetes or insulin resistance. This can be affecting your fertility, whether you are male or female.

DNA Test For Weight Loss – Results

Stubborn Belly fat

Why spend 5 hours in the gym? Imagine achieving your optimal MET (metabolic equivalent) taking the dog for a walk?!
Our laboratory DNA test analyses 4 genes that have been clinically proven to affect your response to diet and exercise.
Stubborn fat e.g. belly fat is a different kind of fat. The result of our DNA Diet may help you. Here’s how:

Is it safe?

YOU GAIN sensible advice so you won’t sacrifice important nutrients or indeed your own time by exercising unnecessarily.

Why are we storing fat around our middle, stubborn fat around our thighs, our hips or upper arms? Stubborn belly fat is a different kind of fat that leads to all kinds of health complications. Taking this DNA test doesn’t just highlight WHY diets have failed us in the past….

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat

 

Feeling discomfort, low in energy, lacking confidence that comes with stubborn fat and being tired all the time?

DNA Test For Weight Loss

DNA Diet Test analyses for healthy weight loss at Susannah Makram Clinics gives clear:

(1) % values for optimal fats, carbs, proteins to consume daily for healthy weight loss.
(2) Suggestion for which proteins, carbs, fats you should consume daily for your healthy weight loss
(3) Clear instructions on how to achieve your optimal MET on a day by day, week by week basis

Our genes might hold the key to understanding why diets have failed in the past. We call the study of how this works epigenetics.

Why take the DNA Diet Test for Weight Loss at Susannah Makram Clinics

From your buccal swab sample we have used a process, called the Polymerase Chain Reaction (PCR). This copies the DNA of your genes many times over. This means we can generate sufficient quantities to analyse your genetic material. This is not uncomfortable at all and is all over very quickly!


The DNA Diet test for weight loss lets us identify unique DNA sequences in some of your genes. You get these results within 7-10 working days in hard copy or email, however you prefer to receive them.


Identifying unique DNA sequences

Certain changes (polymorphisms) in these genes have been studied in detail. Evidence correlates these polymorphisms with your weight management and response to specific food. See these in your DNA Test For Weight Loss Results. (e.g. below)


 

DNA Test For Weight Loss

Taking the buccal swab sample

  • The term ‘Buccal swab’ refers to a DNA collection process involving cells taken from the cheek (from the inside mouth area).
  • Buccal Swabs are sterile. Therefore, it is essential to preserve a sterile test environment. They are produced for medical use. Unless you are allergic to cotton, they should not cause an irritation.
  • An advantage of a Buccal swab is that it allows you to take a DNA sample, in a non invasive way, that is accurate.
  • Buccal swabs should be taken when your mouth is empty. It is best if you swallow first, then swab the inside of your cheek for approximately 30 seconds. The feel is an impression as hard as if you were brushing your teeth.
  • Having a cold should not cause contamination or interferences to your Buccal Swab Sample of DNA testing

Your DNA Test For Weight Loss Results Explained

Not only will the test determine the percentage quantity of fat, protein and the amount of carbohydrate you should be eating but also the type of fat exactly and what type of carbohydrate exactly.

whatisacarb2

whatisafat

Four primary diet and lifestyle factors

i) exercise, ii) obesity risk, iii) sensitivity to carbohydrates and iv) sensitivity to saturated fats.

Your DNA Test For Weight Loss makes a complete assessment of weight management, both environmental factors (diet and lifestyle) and previous medical history need to be considered in conjunction with the accompanying genetic profile.


Only gene variants that have a beneficial, moderate or high impact on metabolic processes are analysed. These are described in detail in your report. Your report is delivered to you once the laboratory investigation on your buccal swab test has been processed. These gene variants will have impact or a mild impact to your personalised nutrition The required alteration or tweaking is made to your Naturopathic Portfolio

Gene Name for each Area of Activity is reported. The areas of activity of interest in the DNA Test for Weight Loss are:

DNA Weight Loss

DNA Weight Loss

Metabolism and Absorption    FABP2 Ala54Thr PPARG Pro12Ala     ADRB2 Arg16Gly     ADRB2 Gln27Glu   APOA5 T>C
Fat metabolism, obesity and satiety    APOA2 -265 T>C
Regulation of metabolism and feeding behaviour    MC4R T>C
Insulin sensitivity and regulation of energy intake  FTO T>A   TCF7L2 C>T
Exercise responsiveness     ADBR3 Trp64Arg
Circadian rhythms     CLOCK T>C
Fat storage      PLIN G>A
Inflammation     TNFA -308 G>A
Taste sensitivity    TAS1R2       SLC2A2 (encoding GLUT2)
Addictions and Overeating      DRD2

Genetic variations for each named gene are stated. Your Results and Gene Impact are in printed out for you in the list above.

Each gene tested has an impact score in your DNA Weight Loss Report

NO IMPACT
LOW IMPACT
MEDIUM IMPACT
HIGH IMPACT

These results are only a guideline. You are as unique as your DNA.  Eat. Drink. Take. Make. Your Naturopathic Portfolio is Safe, Clinical, Practical, Effective.

Vitamin D2 and D3

Vitamin D Guidelines

Should we all take Vitamin D tablets? As response to prevalent vitamin D deficiency signs seen globally Vitamin D from food is more readily available. This is mainly because it has been added. Vitamin D fortified food is plentiful because few foods are natural sources of vitamin D. There’s a vast array of vitamin D supplements on the market.


Giving obese teenagers extra vitamin D pills can elevate their cholesterol and fat-storing triglycerides levels.


Vitamin D, Obesity, Adolescence

Researchers from the Mayo Clinic conducted a study. The paper was published in the journal Pediatric Obesity. They investigated obesity and discovered that Vitamin D does not bring any benefits to obese teens when it comes to heart health or diabetes risk. Moreover Vitamin D can on the contrary be harmful, leading to increased levels of cholesterol and triglycerides.

The findings of the study could be influenced by the fact that the study involved only a small number of participants lasted for a short period of time. Larger, placebo-controlled studies are required to examine the long-term effects of vitamin D supplementation on teens and children, however.


 

Differences between D3 and D2 d Vitamins

The term “vitamin D” refers to several different forms of this vitamin. Two forms: Vitamin D2 and D3 are important in humans: vitamin D2 – which is made by plants – and vitamin D3, which is made by human skin when exposed to sunlight.

Vitamin D, Obesity

Vitamin D, Obesity

Foods fortified vitamin D2 and D3.

The process by which the body makes vitamin D is complex. It starts when the skin absorbs rays in the invisible ultraviolet B (UVB) part of the light spectrum. The liver and the kidneys also participate to make a form of the vitamin that the body can use.

Vitamin D Deficiency

Vitamin D deficiency — when the level of vitamin D in your body is too low — can cause your bones to become thin, brittle or misshapen. The role of vitamin D and insulin resistance, high blood pressure, and immune function — and how these relate to heart disease and cancer — is under investigation.

Vitamin D, Obesity, Adolescence

Vitamin D, Obesity, Adolescence

Although the amount of vitamin D adults get from their diet is often less than what’s recommended, exposure to sunlight can make up for the difference. For most adults, vitamin D deficiency is not a concern. However, some groups — particularly people with dark skin and adults older than age 65 — may not get enough vitamin D in their diet or get enough sunlight for their bodies to produce it.

RDA Vitamin D

The recommended dietary allowance (RDA) for adults is 600 IU of vitamin D a day. That goes up to 800 IU a day for those older than age 70.

To meet this level, choose foods that are rich in vitamin D. For example, choose fortified foods such as milk and yoghurt and fatty fish such as salmon, trout, tuna and halibut.

Do not over do it, though. Very high levels of vitamin D have not been shown to provide greater benefits. In fact, too much vitamin D has been linked to other health problems.

The National Institute of Clinical Excellence (NICE) recommends supplements for pregnant or breastfeeding women and their children from six months to four years.

If you are concerned about whether you are getting enough vitamin D and whether this might be the cause of your health concerns you should discuss these with your health specialist. See what they can do for you straight away. If a vitamin supplement is be beneficial to you, the right supplement that is bioavailable, is prescribed as part of an up-to-date Naturopathic Portfolio.


Safe, clinical, practical and effective.


Call  020 7060 3181