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Fat Burning

Posted on: by Susannah No Comments

Genetic testing

Do you have the fat gene? Researchers discovered the fat gene so now we understand fat burning better. Taking a sample of your DNA is a simple procedure.

Why weight loss matters

Obesity accounts for higher risk of disease and illness. It’s a worldwide epidemic. Surgery can help if you choose the right surgery. Also, follow your Naturopathic portfolio for weight loss that targets stubborn belly fat.

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat 

Regardless of your overall weight, having a large amount of belly fat increases your risk of: See references: (1)  &  (2) 

  • Cardiovascular disease
  • Insulin resistance and type 2 diabetes
  • Colorectal cancer
  • Sleep apnea
  • Premature death from any cause
  • High blood pressure

Obesity rates are rising rapidly in the UK and could lead to 90% of men and 80% of women being overweight or obese by the year 2050. Currently, 16 million days are lost per year due to obesity-related issues.

Serious about fat loss or healthy weight loss? Think you’ll live in the gym? Read on…

Age and genetics may contribute to gaining belly fat

Obesity is the result of a complex pathophysiological pathway involving many factors that control adipose tissue metabolism and deposits of stubborn belly fat. Cytokines, free fatty acids and insulin all play a part and genetic defects are likely to have a significant effect on the fine balance of this process.
Nam H, Ferguson BS, Stephens JM, et al; Impact of obesity on IL-12 family gene expression in insulin responsive tissues. Biochim Biophys Acta.2013 Jan;1832(1):11-9

Do you have the fat gene? Researchers discovered the fat gene so now we understand fat burning better. Taking a sample of your DNA is a simple procedure. If you’re serious about fat loss or healthy weight loss you don’t do all the work with no reward.
Think it’s about living in a gym? Read on…

WHO BENEFITS from DNA testing for healthy weight loss?

  • 20+years male or female with stubborn belly fat – failed attempts at dieting previously – MUST BE an otherwise healthy individual (pass initial screening at the Clinical Nutritional consultation)
  • 35+ years male or female with sudden unexplained weight gain or stubborn belly fat – other ageing factors must be considered and treated separately by thorough history taking, physical examination and (special) investigations (blood work) 

DNA weight loss test

The DNA Test panel is based on genetic differences in nutrient metabolism and body fat regulation or stubborn belly fat. The results can help form building blocks for signs of ageing or unexplained stubborn fat or weight gain.

Obesity is the result of a complex pathophysiological pathway involving many factors that control adipose tissue metabolism and deposits of stubborn belly fat. Cytokines, free fatty acids and insulin all play a part and genetic defects are likely to have a significant effect on the fine balance of this process.
Nam H, Ferguson BS, Stephens JM, et al; Impact of obesity on IL-12 family gene expression in insulin responsive tissues. Biochim Biophys Acta.2013 Jan;1832(1):11-9

stubborn belly fat

stubborn belly fat

KRS2 is one gene that has recently been identified as being implicated in obesity and metabolic rate. DNA sequencing in over 2,000 obese individuals identified multiple mutations of the KRS2 gene, and mutation carriers exhibited severe insulin resistance and a reduced metabolic rate. It may be that modulation of KSR2-mediated effects may have the potential to have therapeutic implications for obesity.
Pearce LR, Atanassova N, Banton MC, et al; KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell. 2013 Nov 7;155(4):765-77.

 

Fat burning

Your Naturopathic Portfolio for weight loss targets stubborn belly fat by fat burning. It converts the complex; the science into one simple and healthy solution that is life changing. For healthy fat burning & effective weight loss:

Eat. Drink. Take. Make. In The Four Phases is:
Safe –  For the right candidate
Clinical – Proven to work for real life subjects
Practical – Works around only your lifestyle. sample menus, what to keep at home and what to eat when out and about or travelling or doing what YOU do on a day-to-day basis (subject to change).
Effective – Impossible not to follow. Just ask Julius.

Weight Loss Pictures

Weight Loss Pictures

 

 Julius achieved this while with HSBC Private Bank, as Global Head of the Wealth Client. He did it. You can too when you book your consultation with Susannah here

* In adults the diagnosis of obesity is most commonly made using levels. BMI is calculated as weight in kilograms (kg) divided by height in metres squared (m2). Ideal BMI is 18.5 to 24.9 kg/m2.The following classification is advised by NICE:

  • A BMI of 25-29.9 kg/m2 is overweight.
  • A BMI of 30-34.9 kg/m2 is obese (Grade I).
  • A BMI of 35-39.9 kg/m2 is obese (Grade II).
  • A BMI of ≥40 kg/m2 is obese (Grade III) or morbidly obese, meaning that weight is a real and imminent threat to health.

DNA Test For Weight Loss – Results

Stubborn Belly fat

Why spend 5 hours in the gym? Imagine achieving your optimal MET (metabolic equivalent) taking the dog for a walk?!
Our laboratory DNA test analyses 4 genes that have been clinically proven to affect your response to diet and exercise.
Stubborn fat e.g. belly fat is a different kind of fat. The result of our DNA Diet may help you. Here’s how:

Is it safe?

YOU GAIN sensible advice so you won’t sacrifice important nutrients or indeed your own time by exercising unnecessarily.

Why are we storing fat around our middle, stubborn fat around our thighs, our hips or upper arms? Stubborn belly fat is a different kind of fat that leads to all kinds of health complications. Taking this DNA test doesn’t just highlight WHY diets have failed us in the past….

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat

 

Feeling discomfort, low in energy, lacking confidence that comes with stubborn fat and being tired all the time?

DNA Test For Weight Loss

DNA Diet Test analyses for healthy weight loss at Susannah Makram Clinics gives clear:

(1) % values for optimal fats, carbs, proteins to consume daily for healthy weight loss.
(2) Suggestion for which proteins, carbs, fats you should consume daily for your healthy weight loss
(3) Clear instructions on how to achieve your optimal MET on a day by day, week by week basis

Our genes might hold the key to understanding why diets have failed in the past. We call the study of how this works epigenetics.

Why take the DNA Diet Test for Weight Loss at Susannah Makram Clinics

From your buccal swab sample we have used a process, called the Polymerase Chain Reaction (PCR). This copies the DNA of your genes many times over. This means we can generate sufficient quantities to analyse your genetic material. This is not uncomfortable at all and is all over very quickly!

The DNA Diet test for weight loss lets us identify unique DNA sequences in some of your genes. You get these results within 7-10 working days in hard copy or email, however you prefer to receive them.

Identifying unique DNA sequences

Certain changes (polymorphisms) in these genes have been studied in detail. Evidence correlates these polymorphisms with your weight management and response to specific food. See these in your DNA Test For Weight Loss Results. (e.g. below)

 

DNA Test For Weight Loss

Taking the buccal swab sample

  • The term ‘Buccal swab’ refers to a DNA collection process involving cells taken from the cheek (from the inside mouth area).
  • Buccal Swabs are sterile. Therefore, it is essential to preserve a sterile test environment. They are produced for medical use. Unless you are allergic to cotton, they should not cause an irritation.
  • An advantage of a Buccal swab is that it allows you to take a DNA sample, in a non invasive way, that is accurate.
  • Buccal swabs should be taken when your mouth is empty. It is best if you swallow first, then swab the inside of your cheek for approximately 30 seconds. The feel is an impression as hard as if you were brushing your teeth.
  • Having a cold should not cause contamination or interferences to your Buccal Swab Sample of DNA testing

Your DNA Test For Weight Loss Results Explained

Not only will the test determine the percentage quantity of fat, protein and the amount of carbohydrate you should be eating but also the type of fat exactly and what type of carbohydrate exactly.

whatisacarb2

whatisafat

Four primary diet and lifestyle factors

i) exercise, ii) obesity risk, iii) sensitivity to carbohydrates and iv) sensitivity to saturated fats.

Your DNA Test For Weight Loss makes a complete assessment of weight management, both environmental factors (diet and lifestyle) and previous medical history need to be considered in conjunction with the accompanying genetic profile.

Only gene variants that have a beneficial, moderate or high impact on metabolic processes are analysed. These are described in detail in your report. Your report is delivered to you once the laboratory investigation on your buccal swab test has been processed. These gene variants will have impact or a mild impact to your personalised nutrition.  The required alteration or tweaking is made to your Naturopathic Portfolio

Gene Name for each Area of Activity is reported. The areas of activity of interest in the DNA Test for Weight Loss are:

DNA Weight Loss

DNA Weight Loss

Metabolism and Absorption    FABP2 Ala54Thr PPARG Pro12Ala     ADRB2 Arg16Gly     ADRB2 Gln27Glu   APOA5 T>C
Fat metabolism, obesity and satiety    APOA2 -265 T>C
Regulation of metabolism and feeding behaviour    MC4R T>C
Insulin sensitivity and regulation of energy intake  FTO T>A   TCF7L2 C>T
Exercise responsiveness     ADBR3 Trp64Arg
Circadian rhythms     CLOCK T>C
Fat storage      PLIN G>A
Inflammation     TNFA -308 G>A
Taste sensitivity    TAS1R2       SLC2A2 (encoding GLUT2)
Addictions and Overeating      DRD2

Genetic variations for each named gene are stated. Your Results and Gene Impact are in printed out for you in the list above.

Each gene tested has an impact score in your DNA Weight Loss Report

NO IMPACT
LOW IMPACT
MEDIUM IMPACT
HIGH IMPACT

These results are only a guideline. You are as unique as your DNA.  Eat. Drink. Take. Make. Your Naturopathic Portfolio is Safe, Clinical, Practical, Effective.

Bariatric diet

Bariatric surgery

Considering bariatric surgery? It’s likely someone we know has healthy weight loss success with this surgery. The most common bariatric surgery procedures are gastric bypass, sleeve gastrectomy, adjustable gastric band and biliopancreatic diversion with duodenal switch.

Weight loss surgery

Knowing health risks of obesity means offering patient choice. At Susannah Makram clinics we feel you should know about options available to you. Also, you should know what to expect by choosing your healthy weight loss route.

Still wondering about taking ownership of your health? Think you’re too young, healthy, don’t qualify?
We’ve made it easy for to break down the routes of obesity treatment.

-> Fast Fact: Did you know that it may be advisable to seek a two week low calorie and mostly liquid diet to prepare you for your surgery?

Q. 1) Which Bariatric surgery for weight loss is right for me?

  • SAFE The safety of bariatric surgery varies considerably. It depends on your personal health and medical history. Safety varies based on the type of operation you have and the experience of both surgeon and hospital.
  • CLINICAL Speak frankly to your specialist. Don’t rely on previous experience of others or information on the internet.
  • PRACTICAL Measure your perceived success with that of your surgeon’s. Re-assess these when your are ready to take responsibility for your current lifestyle. Your nutritional habits and lifestyle need assessment first. This helps you make an informed decision, that is both realistic and optimistic. The right bariatric diet is crucial at every stage.
  • EFFECTIVE Only you can answer this important question. After you consider the medical evidence for surgery and facts. Look at the facts regarding risks and benefits of each procedure.

Q. 3) Is bariatric surgery the solution to Type 2 Diabetes and Obesity?

Bariatric surgery is also known as Obesity surgery. These include: gastric banding, gastric bypass, sleeve gastrectomy and duodenal switch. It is usually undertaken laparoscopically. The most commonly used method in the UK is a gastric bypass.

NICE Guidelines offer an expedited assessment for bariatric surgery. This is to people with a BMI of 35 or over who have recent-onset type 2 diabetes. The GDG considered that recent-onset type 2 diabetes would include those people whose diagnosis has been made within a 10-year time frame.

Classification of Obesity. Note: if you are of Asian origin, you may be considered for weight loss surgery at a lower BMI. This is because the risks of being overweight kick in at a lower BMI in people of Asian origin.

Bariatric Diet

Q. 4) Why are the first two years of bariatric diet after bariatric surgery important?

You will not absorb certain vitamins and minerals in the same way after your operation. You’ll need to take some supplements as advised by your specialist team.
The levels of these will be monitored for the rest of your life. This includes blood tests for your levels of iron, calcium, copper, zinc, vitamin D, and vitamin B12.

bariatric diet

bariatric diet

Q. 5) What the risks or complications of bariatric surgery for weight loss?

Weight loss surgery carries real risks. As many as 10% of people have complications afterward. Unpleasant side-effects include: Nausea, vomiting, diarrhoea.  3% of the time serious complications that are life-threatening occur: blood clot to the lungs -pulmonary embolism, heart attack, leaks in new surgical gut connections, bleeding ulcers. This is higher for people over 60. Even after successful weight loss surgery, other problems are common. These include gallstones often requiring gall bladder removal. Vitamin deficiencies from malnutrition or malabsorption – poor absorption of nutrients, sagging skin requiring body contouring surgery. WHAT’S A FUNCTIONAL BARIATRIC DIET EXACTLY? –> Read on to find out…

-> Fast Fact –  The best way to summarise the pros and cons of bariatric surgery are here     [tweetthis]-> Fast Fact -The best way to summarise the #pros & #cons of #bariatric surgery[/tweetthis]

Q. 6) What makes bariatric surgery successful for some not for others? Success depends on your ability to follow.  Keep reading to find out about the functional bariatric diet.

Weight loss surgery is not a cure for obesity. Rather it can be a tool to help you lose weight. Losing weight for many is about living a healthier, longer and more fulfilling life.

Long-term effects of bariatric surgery are still being studied. Nutritional deficiencies can arise over time. Periodic blood tests are required to help ensure nutritional balance. It is recommended that you do a series of tests every three months for the first year. Annual tests should follow for the rest of your life.

In addition to a complete blood count (CBC), other tests will measure levels of: alanine aminotransferase (ALT). albumin. alkaline phosphatase. aspartate aminotransferase (AST). calcium, cholesterol panel. direct and total bilirubin. electrolytes. fasting glucose. ferritin. folate. hemoglobin A1c. iron saturation and transferring magnesium, phosphorus, total protein and vitamin B12. You may have tests to measure your levels of thiamine and vitamin D.

Q. 7) Does functional nutrition for weight loss work with bariatric surgery? What’s a bariatric diet? 

Yes. Your Naturopathic Nutritional Portfolio For Weight Loss is in the four phases. Your portfolio is:

  1. SAFE. Depends on our health story. 
  2. CLINICAL.  For best possible short and long term outcome for: Biliopancreatic Diversion with Duodenal Switch, Adjustable Gastric Band, Roux-en-Y Gastric Bypass, Sleeve Gastrectomy
  3. PRACTICAL. We don’t live in a spa. So let’s be realistic. Local, minimal lifestyle changes for maximal health and comfort.
  4. EFFECTIVE. Eat. Drink. Take. Make. Personalised nutrition around your lifestyle.
  • PHASE ONE – Preparation is key to lower the chances of complications that can arise with surgery & to improve rate of recovery
  • PHASE TWO – Adapting to your new gut environment
  • PHASE THREE – Making your microbiome and DNA markers for obesity work to improve metabolic function & energy levels
  • PHASE FOUR – Performance, endurance, perceived capability of body & mind is enhanced for prevention of illness & so that your surgery is a continued success

Health Risks Of Obesity

Posted on: by Susannah 1 Comment

What is Obesity

In an adult the diagnosis of obesity is most commonly made using BMI levels. These provide a measure to be viewed in parallel with the health risks of obesity. BMI is calculated as weight in kilograms (kg) divided by height in metres squared (m2). Ideal BMI is 18.5 to 24.9 kg/m2. The following classification is advised by NICE:

  • A BMI of 25-29.9 kg/m2 is overweight.
  • A BMI of 30-34.9 kg/m2 is obese (Grade I).
  • A BMI of 35-39.9 kg/m2 is obese (Grade II).
  • A BMI of ≥40 kg/m2 is obese (Grade III) or morbidly obese, meaning that weight is a real and imminent threat to health.

Waist circumference in men:

  • <94 cm is defined as low risk.
  • 94 to 102 cm is defined as high risk.
  • >102 cm is defined as very high risk.

Waist circumference in women:

  • <80 cm is defined as low risk.
  • 80 to 88 cm is defined as high risk.
  • >88cm is defined as high risk.

Waist circumference is used in combination with BMI to assess your health risk of obesity       [tweetthis]Waist circumference is used in combination with #BMI to assess #health risk of #obesity[/tweetthis]

Obesity and Genetics

Obesity is the result of a complex pathophysiological pathway involving many factors that control adipose tissue metabolism. Cytokines, free fatty acids and insulin all play a part and genetic defects are likely to have a significant effect on the fine balance of this process. Nam H, Ferguson BS, Stephens JM, et al; Impact of obesity on IL-12 family gene expression  in insulin responsive tissues. Biochim Biophys Acta. 2013 Jan;1832(1):11-9. 

Obesity and Health

Obesity and Health

KRS2 is one gene that has recently been identified as being implicated in obesity and metabolic rate. DNA sequencing in over 2,000 obese individuals identified multiple mutations of the KRS2 gene, and mutation carriers exhibited severe insulin resistance and a reduced metabolic rate. It may be that modulation of KSR2-mediated effects may have the potential to have therapeutic implications for obesity.
Pearce LR, Atanassova N, Banton MC, et al; KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell. 2013 Nov 7;155(4):765-77.

Find Out More…

Living with morbid obesity means living at risk for serious health conditions for both men and women combined where applicable. For example, the health risks of obesity are – in terms of the following diseases:-

Type 2 Diabetes
Hypertension
Myocardial Infarction
Colon Cancer
Angina Pectoris
Gall Bladder Disease
Ovarian cancer
Osteoarthritis
Stroke

Obesity and Health

Obesity increases the risk of breast cancer. It also increases the risk of carcinoma of the endometrium. Polycystic Ovary Syndrome PCOS is usually associated with obesity, as is stress incontinence. Obesity impairs fertility in males and females. Obesity increases the risk of fatty liver, along with other features of the metabolic syndrome. Obesity is an important risk factor in the development of chronic respiratory disorders such as COPD, asthma, obesity hypoventilation syndrome, obstructive sleep apnoea. If the person develops a surgical condition, diagnosis is more difficult and almost every postoperative complication is more frequent, including deep vein thrombosis DVT chest infection and wound dehiscence. Not only is osteoarthritis  more common but treatments such as total hip replacements are more likely to be problematical in obesity.

Genetics of Stubborn Belly Fat

Posted on: by Susannah 2 Comments

Belly Fat Stubborn 

At Susannah Makram Clinics we test for 13 genes impacting metabolism and exercise. Isn’t it frustrating exercising and dieting but never losing weight – the stubborn belly fat?

Healthy weight loss requires knowledge found in our GENES.
This DNA test provides specific information regarding fat distribution so we can burn stubborn belly fat with the right changes to our diet,

Stubborn body fat and body mass index BMI in particular have genes or SNPs we’re interested in. Do they hold the key to your successful healthy weight loss?

Let’s not waste more time on the wrong diet. In fact, stop dieting. These genes all meet stringent criteria for utility in genetic screening tests. Start losing stubborn fat like belly fat.

Fat Gene

Fat Gene

 

Lose Belly Fat

What’s the right percentage of carbs, fat, protein for us to lose weight?

What genetics are involved to get rid of stubborn belly fat?

Your test results may tell you the personalised answers you need to achieve your healthy weight loss goals.

All genes tested meet the following stringent criteria for utility in genetic screening tests:

Fat Gene

Fat Gene

  • Have proven biological function. Many of the genetic variations in the test panel produce a change in the amino acid structure of the protein and change theactivity of the protein. Other variations in the panel affect transcription factors in DNA-based communications.
  • Have a plausible biological role in weight management. For example, some of the gene variations produce a change in the amount of fat absorbed from a meal or alter carbohydrate metabolism that has a direct correlation to stubborn belly fat.
  • Have evidence from clinical studies, that individuals with different genotypes have a differential response to either certain diets or different levels of physical activity.

Weight Loss

Weight Management Genetic Testing has been all over the news in the US – The Today Show, The Wall Street Journal, CBS Morning News – In America they are calling it personalised medicine

We are calling it boundary breaking functional medicine at Susannah Makram Clinics because we know who this test will work for and why so there is no time wasting and false hope

The DNA test for healthy weight loss

Fat Gene

Fat Gene

  • Genetic testing

    Who is the right candidate? Find out here

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