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Fat Burning

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Genetic testing

Do you have the fat gene? Researchers discovered the fat gene so now we understand fat burning better. Taking a sample of your DNA is a simple procedure.

Why weight loss matters

Obesity accounts for higher risk of disease and illness. It’s a worldwide epidemic. Surgery can help if you choose the right surgery. Also, follow your Naturopathic portfolio for weight loss that targets stubborn belly fat.

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat 

Regardless of your overall weight, having a large amount of belly fat increases your risk of: See references: (1)  &  (2) 

  • Cardiovascular disease
  • Insulin resistance and type 2 diabetes
  • Colorectal cancer
  • Sleep apnea
  • Premature death from any cause
  • High blood pressure

Obesity rates are rising rapidly in the UK and could lead to 90% of men and 80% of women being overweight or obese by the year 2050. Currently, 16 million days are lost per year due to obesity-related issues.

Serious about fat loss or healthy weight loss? Think you’ll live in the gym? Read on…

Age and genetics may contribute to gaining belly fat

Obesity is the result of a complex pathophysiological pathway involving many factors that control adipose tissue metabolism and deposits of stubborn belly fat. Cytokines, free fatty acids and insulin all play a part and genetic defects are likely to have a significant effect on the fine balance of this process.
Nam H, Ferguson BS, Stephens JM, et al; Impact of obesity on IL-12 family gene expression in insulin responsive tissues. Biochim Biophys Acta.2013 Jan;1832(1):11-9

Do you have the fat gene? Researchers discovered the fat gene so now we understand fat burning better. Taking a sample of your DNA is a simple procedure. If you’re serious about fat loss or healthy weight loss you don’t do all the work with no reward.
Think it’s about living in a gym? Read on…

WHO BENEFITS from DNA testing for healthy weight loss?

  • 20+years male or female with stubborn belly fat – failed attempts at dieting previously – MUST BE an otherwise healthy individual (pass initial screening at the Clinical Nutritional consultation)
  • 35+ years male or female with sudden unexplained weight gain or stubborn belly fat – other ageing factors must be considered and treated separately by thorough history taking, physical examination and (special) investigations (blood work) 

DNA weight loss test

The DNA Test panel is based on genetic differences in nutrient metabolism and body fat regulation or stubborn belly fat. The results can help form building blocks for signs of ageing or unexplained stubborn fat or weight gain.

Obesity is the result of a complex pathophysiological pathway involving many factors that control adipose tissue metabolism and deposits of stubborn belly fat. Cytokines, free fatty acids and insulin all play a part and genetic defects are likely to have a significant effect on the fine balance of this process.
Nam H, Ferguson BS, Stephens JM, et al; Impact of obesity on IL-12 family gene expression in insulin responsive tissues. Biochim Biophys Acta.2013 Jan;1832(1):11-9

stubborn belly fat

stubborn belly fat

KRS2 is one gene that has recently been identified as being implicated in obesity and metabolic rate. DNA sequencing in over 2,000 obese individuals identified multiple mutations of the KRS2 gene, and mutation carriers exhibited severe insulin resistance and a reduced metabolic rate. It may be that modulation of KSR2-mediated effects may have the potential to have therapeutic implications for obesity.
Pearce LR, Atanassova N, Banton MC, et al; KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell. 2013 Nov 7;155(4):765-77.


Fat burning

Your Naturopathic Portfolio for weight loss targets stubborn belly fat by fat burning. It converts the complex; the science into one simple and healthy solution that is life changing. For healthy fat burning & effective weight loss:

Eat. Drink. Take. Make. In The Four Phases is:
Safe –  For the right candidate
Clinical – Proven to work for real life subjects
Practical – Works around only your lifestyle. sample menus, what to keep at home and what to eat when out and about or travelling or doing what YOU do on a day-to-day basis (subject to change).
Effective – Impossible not to follow. Just ask Julius.

Weight Loss Pictures

Weight Loss Pictures


 Julius achieved this while with HSBC Private Bank, as Global Head of the Wealth Client. He did it. You can too when you book your consultation with Susannah here

* In adults the diagnosis of obesity is most commonly made using levels. BMI is calculated as weight in kilograms (kg) divided by height in metres squared (m2). Ideal BMI is 18.5 to 24.9 kg/m2.The following classification is advised by NICE:

  • A BMI of 25-29.9 kg/m2 is overweight.
  • A BMI of 30-34.9 kg/m2 is obese (Grade I).
  • A BMI of 35-39.9 kg/m2 is obese (Grade II).
  • A BMI of ≥40 kg/m2 is obese (Grade III) or morbidly obese, meaning that weight is a real and imminent threat to health.


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Hungry All The Time

Why Hungry All The Time

HUNGRY all the time? After a meal do you FEEL FULL or STILL HUNGRY.. moments later? Trying to lose weight?Following a strict diet? May be DOING A DETOX or cleanse? The weight is not shifting, however.

Being on a healthy eating plan may be a radical change or too many changes all at once. Sometimes we’re pretty good at sticking to this. But when stubborn fat like belly fat sticks, we lose our motivation. Excess “water weight” or feeling bloated  is exceptionally uncomfortable. It also affects our posture and can strain muscles in our upper back.

Here are some reasons why and how you can change this pattern and find your successful weight loss solution.

Hungry All The Time

  1. You did not include enough fibre in your meal – gluten free diets that are prescribed for individuals with gluten intolerance or allergies need to make sure their uptake of dietary fibre (soluble, insoluble) is adequate and supplement accordingly.
    Hungry All The Time

    Hungry All The Time

  2. BPA – BPA is the lining often found in cans that prevent corrosion. BPA is also found in some plastics, like water bottles and other food packaging materials. If you are obese and leptin-resistant, your body is not getting a clear message from the leptin that you are full; you feel hungry because your body still thinks you are starving so your chances of experiency true satiety are merely reduced. So if you are tackling obesity by trying to lose weight, the chances are you might be leptin resistant and as BPA increases leptin levels in the body, and leptin is meant to decrease hunger, this tactic will not work for you.
  3. LEPTIN RESISTANCE  – Do you have a problem where you HAVE TO EAT immediately BEFORE BED to fall asleep — even if you’re not hungry? Do you  wake up in the middle of the night and have to eat again to fall back to sleep? these may be signs of leptin resistance which can be treated directly Leptin, adiponectin, and resistin are produced by the adipose tissue. The protein leptin, a satiety hormone, regulates appetite and energy balance of the body. Leptin resistance is a hallmark of obesity, but its etiology is unknown, and its clinical measurement is elusive.
  4. Your genes – DNA testing for weight loss is a science that makes the way your body reaches its healthy weight loss goal unique. You are as unique as your DNA. Safe, Clinical, Practical, Effective = your weight loss Naturopathic Portfolio  Fat metabolism, obesity and satiety are governed by the genetic influence of APOA2 -265 T>Cgenetic-makeup
  5. You are not eating the right balance of fat, protein and carbohydrate based on your personal weight magnet genetic test report
  6. 90% of human illness can be traced to an unhealthy gut. The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study. If your dietary intake is feeding the “bad bacteria” in your gut, this physiological process may be key to putting a halt on your unsuccessful weight loss that has so far been frustrating.
  7. Nutrients from your food or diet are not being fully absorbed. Side effects of malabsorption are that heavy feeling you get in your gut. Bloating, fatigue and ultimately a reduction in digestive enzyme activity are not a recipe for burning fat. Fat burning may be your healthy weight loss goal. Ultimately, this inability to break down food  can lead to an accumulation of stubborn unwanted fat.

DNA Test For Weight Loss – Results

Stubborn Belly fat

Why spend 5 hours in the gym? Imagine achieving your optimal MET (metabolic equivalent) taking the dog for a walk?!
Our laboratory DNA test analyses 4 genes that have been clinically proven to affect your response to diet and exercise.
Stubborn fat e.g. belly fat is a different kind of fat. The result of our DNA Diet may help you. Here’s how:

Is it safe?

YOU GAIN sensible advice so you won’t sacrifice important nutrients or indeed your own time by exercising unnecessarily.

Why are we storing fat around our middle, stubborn fat around our thighs, our hips or upper arms? Stubborn belly fat is a different kind of fat that leads to all kinds of health complications. Taking this DNA test doesn’t just highlight WHY diets have failed us in the past….

Belly fat is a more dangerous fat

Belly fat is a more dangerous fat


Feeling discomfort, low in energy, lacking confidence that comes with stubborn fat and being tired all the time?

DNA Test For Weight Loss

DNA Diet Test analyses for healthy weight loss at Susannah Makram Clinics gives clear:

(1) % values for optimal fats, carbs, proteins to consume daily for healthy weight loss.
(2) Suggestion for which proteins, carbs, fats you should consume daily for your healthy weight loss
(3) Clear instructions on how to achieve your optimal MET on a day by day, week by week basis

Our genes might hold the key to understanding why diets have failed in the past. We call the study of how this works epigenetics.

Why take the DNA Diet Test for Weight Loss at Susannah Makram Clinics

From your buccal swab sample we have used a process, called the Polymerase Chain Reaction (PCR). This copies the DNA of your genes many times over. This means we can generate sufficient quantities to analyse your genetic material. This is not uncomfortable at all and is all over very quickly!

The DNA Diet test for weight loss lets us identify unique DNA sequences in some of your genes. You get these results within 7-10 working days in hard copy or email, however you prefer to receive them.

Identifying unique DNA sequences

Certain changes (polymorphisms) in these genes have been studied in detail. Evidence correlates these polymorphisms with your weight management and response to specific food. See these in your DNA Test For Weight Loss Results. (e.g. below)


DNA Test For Weight Loss

Taking the buccal swab sample

  • The term ‘Buccal swab’ refers to a DNA collection process involving cells taken from the cheek (from the inside mouth area).
  • Buccal Swabs are sterile. Therefore, it is essential to preserve a sterile test environment. They are produced for medical use. Unless you are allergic to cotton, they should not cause an irritation.
  • An advantage of a Buccal swab is that it allows you to take a DNA sample, in a non invasive way, that is accurate.
  • Buccal swabs should be taken when your mouth is empty. It is best if you swallow first, then swab the inside of your cheek for approximately 30 seconds. The feel is an impression as hard as if you were brushing your teeth.
  • Having a cold should not cause contamination or interferences to your Buccal Swab Sample of DNA testing

Your DNA Test For Weight Loss Results Explained

Not only will the test determine the percentage quantity of fat, protein and the amount of carbohydrate you should be eating but also the type of fat exactly and what type of carbohydrate exactly.



Four primary diet and lifestyle factors

i) exercise, ii) obesity risk, iii) sensitivity to carbohydrates and iv) sensitivity to saturated fats.

Your DNA Test For Weight Loss makes a complete assessment of weight management, both environmental factors (diet and lifestyle) and previous medical history need to be considered in conjunction with the accompanying genetic profile.

Only gene variants that have a beneficial, moderate or high impact on metabolic processes are analysed. These are described in detail in your report. Your report is delivered to you once the laboratory investigation on your buccal swab test has been processed. These gene variants will have impact or a mild impact to your personalised nutrition The required alteration or tweaking is made to your Naturopathic Portfolio

Gene Name for each Area of Activity is reported. The areas of activity of interest in the DNA Test for Weight Loss are:

DNA Weight Loss

DNA Weight Loss

Metabolism and Absorption    FABP2 Ala54Thr PPARG Pro12Ala     ADRB2 Arg16Gly     ADRB2 Gln27Glu   APOA5 T>C
Fat metabolism, obesity and satiety    APOA2 -265 T>C
Regulation of metabolism and feeding behaviour    MC4R T>C
Insulin sensitivity and regulation of energy intake  FTO T>A   TCF7L2 C>T
Exercise responsiveness     ADBR3 Trp64Arg
Circadian rhythms     CLOCK T>C
Fat storage      PLIN G>A
Inflammation     TNFA -308 G>A
Taste sensitivity    TAS1R2       SLC2A2 (encoding GLUT2)
Addictions and Overeating      DRD2

Genetic variations for each named gene are stated. Your Results and Gene Impact are in printed out for you in the list above.

Each gene tested has an impact score in your DNA Weight Loss Report


These results are only a guideline. You are as unique as your DNA.  Eat. Drink. Take. Make. Your Naturopathic Portfolio is Safe, Clinical, Practical, Effective.

Safe, clinical, practical and effective.

Call  020 7060 3181