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Sperm DNA testing UK

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Sperm DNA

Testing Sperm DNA damage  can help couples optimise diet and lifestyle for fertility. DNA fragmentation testing, The Tunel assay and sperm chromatin dispersion Halo test will be compared. Read on. At Susannah Makram Clinics we offer the best type of sperm DNA fragmentation testing  – a type of male fertility testing. At consultation we address the pros and cons of test so you can decide. Ask us how. 0207 060 3181

Couples – who benefits from a sperm DNA test?

Sperm DNA testing UK consultation . We provide essential information regrading lifestyle and our environment based on your health and fertility story so far. We outline what use of the test means for you and your partner. We can suggest which clinics guide couples to their bespoke treatment, for their particular needs. These include couples with:

  • Unexplained infertility
  • Men with normal semen by semen analysis (normal sperm count and sperm motility) prior to IVF
  • Couples who have had unsuccessful IVF 
  • Couple with no success using ICSI
  • Couples who have had miscarriages

Sperm DNA damage – Which Test?

The Comet assay – The SpermComet Test – Lewis Fertility testing at Susannah Makram Clinics

Extensive clinical trials and statistics that prove this test is the best indicator for, not only choosing the right treatment, but also to test when Sperm DNA Damage reversal IN THE FOUR PHASES is successful thus.

 

Sperm DNA testing Uk

All testing in and outside of the UK to measure sperm DNA damage are different. The Spermcomet test is described by Prof Lewis and was featured in Daily Mail recently. The current range of sperm DNA tests measure different aspects of DNA damage. The tests all have different sensitivities. The tests also provide information that may or may not provide couples with treatment advice.

The four tests most often used today are: 1) the Comet assay, 2) SCSA, 3) the terminal transferase dUTP nick end labeling (TUNEL) assay, and the 4) Sperm Chromatin Dispersion (SCD or Halo) test.


We want only the best for couple visiting our clinic for consultation. If we recommend the test we use data collected to actively reverse sperm DNA damage. this care pathway is unique for every couple at Susannah Makram Clinics. 


 

The Comet assay – The SpermComet Test

The comet assay is a second generation sperm DNA test. Unlike the other three tests, it quantifies the actual amount of DNA damage per sperm. Super DNSA testing UK – result guide can de found here.

One major advantage of this assay is that it uses only 5000 sperm. Therefore, it is suitable for the assessment of small samples left over from clinical use, or for samples where only a few sperm are available.

The Comet assay can measure both single and double strand breaks. With an additional step, the SpermComet can measure even altered bases.


This is useful because we do not yet know which types of DNA damage are most deleterious to male fertility.       [tweetthis]We do not yet know which types of #DNA damage are most deleterious to #malefertility. [/tweetthis]


The Comet is sensitive, repeatable and capable of detecting damage in every sperm. This is high sensitivity is evident of fertile donors. Since 2010, clinical thresholds for the diagnosis of male infertility and the prediction of successful IVF have been established.

At Susannah Makram Clinics we use The Comet Assay in our laboratory testing


 

The Sperm chromatin structure assay

The SCSA is a fluorescence cell sorter test which measures the susceptibility of sperm DNA to denaturation after exposure to heat or acid conditions.

The clinical threshold for this test is a DNA fragmentation index (DFI) of 30%- that means 30% of the sperm have damage (with quantification into moderate or high damage) and 70% have no detectable damage.

Couples with >30% damage are more likely to have success with ICSI than IVF

The TUNEL assay

The TUNEL assay detects ‘nicks’ (free ends of DNA) by incorporating fluorescent stained nucleotides. This allows the detection of single and double stranded damage.

The TUNEL has major potential but robust clinical thresholds have yet to be established.

The sperm chromatin dispersion (Halo) test

The Halo test is a ‘cheap and convenient’ kit form of sperm DNA testing. It is a simple and inexpensive assay, available in fertility labs for in house use.

Unlike all the other tests, the HALO measures the absence of damage, rather than the damaged DNA in sperm.

One limitation of the assay is that its low-density nucleoids are relatively faint, with less contrasting images.

To date, correlations have been observed between DNA and other sperm parameters. Few correlations between sperm DNA damage and ART outcomes have been established with the Halo test, even in large studies.

Sperm DNA Fragmentation Testing

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When IVF Fails
MORE THAN 60,000 IVF CYCLES take place in Britain each year. Just 24% of these treatments lead to live births. At Susannah Makram Clinics we’re here to use information highlighted below. This helps map out a care pathway centred around optimising your health.    [tweetthis]There are >60,000 #IVF cycles in Britain p.a. Only 24% of these lead to live #births[/tweetthis]

When IVF Fails

IVF Implantation Failure. Why does in vitro fertilisation sometimes fail?

When IVF fails it’s a frustrating situation for couples and their fertility doctors. Sperm DNA Fragmentation Testing results can help be a guide for couples.

Why do we do sperm DNA fragmentation testing at Susannah Makram Clinics London?
Email from client: “We have followed your instructions and the Aneuploidy test went down from 60% to 14% which is a very good result. I feel fine and have lost weight…” — Mr. R (Dubai)

Before booking your appointment with Nutrition Expert Susannah for referral we’ll help assess the need for Sperm Fragmentation Testing. This way you know what to expect when you book your appointment with Susannah. Will this data be helpful in your case, on your fertility journey? The extent of this is covered in your initial consultation when a full history taken.
We use this test at Susannah Makram Clinics London – with use of previous reports and investigations and your medical case history. When it comes to helping you make nutrition and lifestyle changes we answer: How will these benefit you and your partner?
The SpermComet Test for Sperm DNA Fragmentation Testing helps couples decide whether IVF is best first or again. Sperm DNA fragmentation reports guide couples to help them map out their fertility treatment route. At Susannah Makram Clinics we’re here to use this information to map out a care pathway centred around optimising your health.
There is an equation we can use to illustrate the implantation process:

  • Embryo quality + receptivity of uterine lining = chance for implantation and pregnancy
  • We know that many human embryos will arrest (die) before day 5
  • Unfortunately, embryonic arrest also occurs after day 5
  • Some of the embryos that are transferred that ” look good” will die after they are placed in the uterus
  • This is the explanation for IVF failure in the large majority of cases
  • It is usually a weakness in the embryo that leads to failed implantation
  • On the average, only about 25% of transferred embryos continue to develop and become kids
  • This percentage of implanting embryos is greatly dependent on female age – see below
    • About 45% implant under age 35
    • About 15% implant at age 40-42

When IVF fails, couples often ask why the embryos did not stick. When IVF fails we ask why the uterus isn’t accepting the embryos. Rarely is the answer straightforward, unfortunately.

At Susannah Makram Clinics we feel passionately about this. We care greatly that information is provided to patients at all times. Especially in this difficult time, so time is not wasted and that right treatment is offered. We care to avoid heartache.

Unexplained infertility

Unexplained infertility is a frustrating conclusion for couples. It’s a very unsatisfactory diagnosis for couples and clinic alike. In our latest study we have shown that 80% of couples diagnosed with idiopathic infertility have sperm DNA damage (>25% damage per sperm).

This suggests that sperm DNA damage is the cause of infertility in a substantial number of men if we compare these levels of damage we reported in sperm of donor men with proven fertility

When IVF Fails

When IVF Fails

Sperm DNA Fragmentation Testing

WE KNOW:

The percentage of implanting embryos is greatly dependent on female age. Typically female age is the main factor responsible for unexplained infertility. This is especially the case after repeated failure of  IVF cycles. Find out more about this in detail here.

Which couples benefit from a sperm DNA test?

Sperm DNA testing will provide essential information on which clinics can guide couples to bespoke treatment for their particular needs. These include couples with:

  • Unexplained infertility
  • Men with normal semen by semen analysis prior to embarking on IVF
  • Couples who have had unsuccessful IVF
  • Couples who have had miscarriages

Sperm DNA Fragmentation Testing

We are testing Sperm DNA damage so we may guide couples with low damage to intrauterine insemination (IUI) or in vitro fertilization (IVF). We are pro patient choice.

Sperm DNA Fragmentation Testing

Sperm DNA Fragmentation Testing

 

Guiding couples with high DNA damage to ICSI and only couples who would not benefit from testing are advisable but ultimately it is the couples’ choice. With oligo-astheno-terato-zoospermia there is no treatment other than ICSI for couples. It helps to understand what this means. That is why we take the time to explain all options available to couples following any fertility results.

At Susannah Makram Clinics we use the SpermComet Test for Sperm DNA fragmentation testing. Find out why here

6 Reasons: Osteopathy, Nutrition and health

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Functional Osteopathy

Knightsbridge and Chelsea Osteopath Susannah helps optimise professional performance. HOW? Physical therapy techniques unique to osteopathyFunctional osteopathy treats the body as a whole.
How we move is our dynamic posture. Osteopathic techniques with a focus at Susannah Makram Clinics enhance two things: form and function.  We do this to capitalise on our body’s unique inherent strength.
We do this to optimise health. PRO-TIP: Don’t ignore warning signs.

SAFE. CLINICAL. PRACTICAL. EFFECTIVE. Does it always include functional nutrition? 


In London our modern lifestyle means chronic back pain and chronic health concerns recur. —->>>  Why?

Is it stress? What makes us tired all the time? Get stubborn belly fat, skin conditions and poor hair health?
Can  functional nutrition boost performance by a notch after osteopathy?

OSTEOPATHY, NUTRITION CONT’D

When’s the best time to have osteopathy?


“Health is more than the absence of disease. Health is about jobs and employment, education, the environment, and all of those things that go into making us healthy.”


Posture and Health

What does being healthy mean to you? Total body wellness or simply feeling balanced? Form and function. The best way to visualise these two things is via our posture. Our posture and health are interconnected.

Are you fatigued at work? Bloated or experiencing gastrointestinal symptoms of stress and anxiety? Chest pains? Feel like you cannot breath properly, you have aches in your joints? Poor posture can lead to an impairment to blood flow through the chest. This strains the blood vessels below the chest to produce a weakness in blood flow to the brain and cause fatigue (Orthostatic intolerance).

Nutrition and health

An internal chemical and hormonal imbalance sets us up for illness. One example can be seen in this study linking Low Immune Function and Intestinal Bacterial Imbalance to the Etiology of Rheumatoid Arthritis. There’s a case for diet and lifestyle alone to be a potential cause of non specific chronic lower back pain. Osteopaths look to treat the cause of pain or disease. Our training includes studying the pathophysiology of disease. Inflammation must exist for a reason. Pain, therefore, must exist for a reason. Put simply, poor posture from lower back pain or an injury we are accommodating for leads to our disrupted patterns of healthy:

(i) breathing (ii) digestion (iii) sleep (iv) responses to nutrition  (v) respones to stress

osteopathy, nutrition

osteopathy, nutrition


Osteopaths are highly competent healthcare professionals, recognised by the NHS. Osteopathy is a way of detecting, treating and preventing health problems. Osteopathy, nutrition and lifestyle change support is health optimisation. How are you feeling?


Osteopathy, Nutrition

The Missing Link In Functional Care. A clinical background in Osteopathy Matters. 6 Reasons – Osteopathy, Nutrition.

  1. Osteopathy seeks to find dysfunction. All the while we’re examining and treating the body as a whole.
  2. Using our understanding of disease pathophysiology and pain pathways are the greatest diagnostic tools of the osteopath.
  3. Correctly identify the cause or causes linked to why you are seeking nutritional therapy to begin with are the only way to deliver the correct therapy or therapy as treatment.
  4. “You can have inflammation without pain, but there is no pain without inflammation”. One cause of pain is metabolic. A type or stage of inflammation indicates a homeostatic imbalance. Both osteopathy and naturopathy adhere to the principle of helping to create the right environment. This is for optimal homeostatis (balance). It means the body will heal itself, as it does in nature. We help this bodily process to happen to the best of its ability.
  5. Clinically, common tests to diagnose inflammation are erythrocyte sedimentation rate (ESR), white blood cell count, albumin levels (and other biomarkers). These tests are nonspecific. So, an abnormal result might be from a condition unrelated to inflammation. With osteopathy, nutrition and lifestyle as a means of optimising health, it’s important to know about this. Recognising signs and symptoms of acute, sub-acute and chronic inflammatory process, for example. Also, being able to interpret laboratory reports thus, is unique and invaluable for healthy weight loss results, unexplained fatigue etc.
  6. Our hormones have a complicated relationship with our Central Nervous System as well as our Cardiovascular Systems.

Functional testing in osteopathy, nutrition

Conventional medical testing will usually produce a result only when you’ve developed a disease. Often you may feel ill long before there is a “measurable pathology” – you know something is wrong but your tests keep coming back clear. Sound familiar? 

Should I Have My Child Vaccinated?

Are Vaccinations Safe?

The 2014-2015 flu vaccine or flu jab offers protection from currently circulating H1N1 and H3N2 flu strains. As well it offers protection from two strains of influenza B.

Should I have my child vaccinated?

Childhood vaccines protect children from a variety of serious or potentially fatal diseases. These include diphtheria, measles, meningitis, polio, tetanus and whooping cough. Still, you may wonder about the benefits and risks of childhood vaccines – and rightly so.

Vaccines and Immunisations – 10 Facts

  1. To answer the question – should I have my child vaccinated? – we need to fully understand that vaccination prevents deaths every year in all age groups from diphtheria, tetanus, pertussis (whooping cough), and measles. It is one of the most successful and cost-effective public health interventions.
  2. In 2010, an estimated 109 million children under the age of one were vaccinated with three doses of diphtheria-tetanus-pertussis (DTP3) vaccine. These children are protected against infectious diseases that can have serious consequences like illness, disability or death.
  3. An estimated 19.3 million children under the age of of one did not receive DTP3 vaccine. Seventy percent of these children live in ten countries, and more than half of them live in WHO’s Africa and South-East Asia regions.
  4. Over 1 million infants and young children die every year from pneumococcal disease and rotavirus diarrhoea. A large number of these deaths can be prevented through vaccination. Public-private partnerships facilitate the development and introduction of vaccines & the supply of vaccines has been significantly expanded.
  5. Global measles has declined by 74% thanks to intensified vaccination campaigns. Polio cases have decreased by over 99% & annual deaths by neonatal tetanus have fallen

    Are childhood vaccinations safe?

    Are childhood vaccinations safe?

    Susannah is interested in this topic because when you come to see her in clinic you are unwell or sick. There is a medical history or story to this illness – starting from birth. This story is told by your body’s defence mechanisms or immunity. The way your body identifies and then responds to pathogens changes your treatment from PHASE ONE – FOUR. Which of those pathogens also changes your treatment with Susannah.

    The Body Youth Code supports the unique expression of health and vitality for each individual. PHASE ONE: It is important to understand this following. The microbiome plays its role, ensuring your gut health is optimal. This is a foundation upon which the subsequent PHASES 2-4 are built.

    Chronic illness

    You will not feel better from chronic illness unless this (his)story is understood. Susannah’s treatment addresses the cause or causes of health concern. This might be chronic illness, weakness, tiredness, chronic pain. It may be your general inability to improve your health by losing weight. You may want to improve skin health and subsequent appearance. Similarly, creating optimal conditions for fertility, regaining your hair health.

    What is a vaccination and immunisation?

    Adaptive immune systems or non-speciifc immunity are natural unless or until they are provoked. This is by injecting a small amount of weak or dead infectious agent through our skin to trigger a immune response. You are unique and your body will react differently today as it did in the past but how your body will react to treatment today is product of many such factors, that we enquire about at consultation. You can subscribe to Susannah Makram TV to learn a bit more about this process.


  6. Immunisation not only protects children from vaccine-preventable diseases. It also serves as an opportunity to deliver other life-saving measures, such as vitamin A supplements to prevent malnutrition, insecticide-treated nets for protection against malaria and deworming medicine for intestinal worms.
  7. There Are Suspicions That vaccines Cause Autism

    Suspicions that vaccines cause autism exist even though the original study by Andrew Wakefield  that posed this hypothesis has been debunked in many subsequent studies. There are suspicions that the vaccines are poisonous and harmful, rather than protective. There’s also a lack of concern for the diseases the vaccines protect against. Despite much controversy on the topic, researchers have not found a connection between autism and childhood vaccines. In fact, the original study that ignited the debate years ago has been retracted. Although signs of autism may appear at about the same time children receive certain vaccines — such as the measles, mumps and rubella (MMR) vaccine — this is simply a coincidence.

  8. To fully understand the studies on the reproduction of the wild chicken pox virus compared to the vaccine virus in the body, or the data on the safety and efficacy of the vaccine, one would need expertise on microbiology, immunology and statistics.
  9. The vaccination debate isn’t even as simple as to vaccinate or not. Among those who decide to vaccinate their children there are conversations about the recommended vaccine schedule, and if it is too taxing for a child’s young body.
  10. So you are still likely asking the question: should I Have My Child Vaccinated? After all, if vaccines truly worked, then why would the parents of vaccinated children be concerned of risk by exposure to un-vaccinated children? The World Health Organisation  (WHO) underscored this fact in their report titled, Immunization, Vaccines and Biologicals. They wrote that, “Children under two years of age do not consistently develop immunity following vaccination.” Therefore, vaccines can fly “below the radar” of our immune system.

Summary. Should I have my child vaccinated?

Depending on your child’s age and health, you might be able to choose between a flu jab and the nasal spray vaccine:

  • Nasal spray The nasal spray flu vaccine can be given to children 2 years and older. It’s recommended for healthy children ages 2 through 8 years. If the nasal spray is not immediately available, the flu shot should be used. Side effects of the nasal spray might include runny nose, cough, fever, wheezing, headache and muscle aches.
  • Flu jab Flu jabs can be given to children 6 months and older. Side effects might include soreness, redness or swelling where the shot was given, low-grade fever, or muscle aches.

It is also important to consider how many doses of flu vaccine your child needs:

  • 2 doses. If your child has not had the flu vaccine before and he or she is younger than 9, plan for two doses. these 2 doses are given at least four weeks apart. Begin the process as early as possible. If your child is exposed to the flu before the second dose or isn’t able to get the second dose, he or she is more likely to get the flu.
  • 1 dose. If your child has had the flu vaccine before — or your child gets the flu vaccine for the first time at 9 or older — one dose is enough. Timing is still important, though. It takes up to two weeks after vaccination for a child to be fully protected from the flu.

Vaccinations – Protection For Children And The Elderly

Does the flu jab or flu shot or flu or influenza vaccine really protect my child, or even the elderly i.e. vulnerable populations? If you are a parent you are asking again: should I have my child vaccinated? This review is saying there is not enough evidence either way to say anything about the efficacy of vaccines in this vulnerable population. This study seems to suggest that the influenza vaccine is not an evidence-based recommendation but rather a recommendation based on a belief system.


Firstly, if you have made the decision to vaccinate (influenza vaccine specific) your child you should note the following and query your paediatrician or family doctor if:

  • Your child is not feeling well.
  • Your child recently had other vaccines.
  • Your child has any medical conditions. The doctor will likely recommend a flu shot rather than the nasal spray vaccine if your child is younger than 5 and has asthma or a history of wheezing. Similarly, the nasal spray flu vaccine isn’t recommended for children on long-term aspirin treatment or those who have nerve disorders, a weak immune system or certain other medical conditions.
  • Your child is allergic to eggs. The flu vaccine contains tiny amounts of egg protein. If your child has an egg allergy or sensitivity, he or she will likely be able to receive a flu vaccine. However, you might need to take special precautions. This means waiting in the doctor’s office for at least 30 minutes after vaccination in case of a reaction.
  • Your child had a severe reaction to a previous flu vaccine.The flu vaccine is not recommended for anyone who had a severe reaction to a previous flu vaccine. Check with your child’s doctor first, though. Some reactions might not be related to the vaccine.

You should be registered with a GP if you are a resident in the UK. They can offer this vaccination or immunisation service. Yearly flu vaccines are also recommended for adults — especially those who have close contact with young children.

Physiotherapy Osteopathy Chiropractic Difference

Osteopathy and chiropractic

Physiotherapy; osteopathy; chiropractic. What’s the difference? Which physical therapy is for me? Low down:
1. NHS – Osteopathy and chiropractic aren’t available on the NHS in all parts of the UK. Even in places where osteopathy is available, there may be limited availability. The same applies for Chiropractic treatment.


Finding Osteopathy Chiropractic Difference interesting? Don’t forget to subscribe to Susannah Makram TV 


Osteopathy and Physiotherapy

Many physiotherapists work as part of a multi-disciplinary team. They can work from NHS hospitals. Also, from community based organisations, private hospitals and clinics, sports clubs, charities and workplaces. Physiotherapists and osteopaths and chiropractors all use manual therapy or physical therapy.
That’s to say, we all use touch, to varying degrees. The skill of an Osteopath is high in palpation. The physiotherapist generally uses ultrasound, acupuncture, taping and creams and so on more so than the osteopath and chiropractor. Much hands on treatment technique differs somewhat. Manipulation or adjustment techniques used by the chiropractor, physiotherapist and osteopath – HVT or HVLAT – High velocity, low amplitude thrust techniques – are unique to the profession.

2. Qualifications – physiotherapy osteopathy chiropractic difference

Osteopaths complete a four – or five-year honours degree programme (bachelor’s or master’s), which involves at least 1,000 hours of clinical training. Some osteopaths are qualified to PhD level.
Chiropractors’ 4-year Chiropractic Degree programme ensures completion of bachelor of human science degree completion.
Physiotherapists complete a three-year full-time BSc (Hons ) programme.

Physiotherapy osteopathy chiropractic difference

3. NICE Guidelines – physiotherapy osteopathy chiropractic difference

There’s good evidence that osteopathy is effective for the treatment of persistent lower back pain. The National Institute for Health and Care Excellence (NICE) recommends it as a treatment for this condition.

Physiotherapy Osteopathy Chiropractic Difference

Physiotherapy Osteopathy Chiropractic Difference

Currently, (NICE) recommends manual therapy that might include spinal manipulation (as practiced by chiropractors) as a treatment option for persistent lower back pain.

The National Institute for Health and Care Excellence (NICE) advises that manual therapy can be used to treat persistent low back pain.

4. Legal – Primary Certifying Body – physiotherapy osteopathy chiropractic difference

It’s illegal to practice osteopathy in the UK unless registered with General Osteopathic Council. It’s illegal to practise o practice chiropractic in the UK unless registered General Chiropractic Council. Physiotherapy, likewise, unless registered with the Chartered Society of Physiotherapy.


Physiotherapy Osteopathy Chiropractic Difference – FAST FACTS

5.  Osteopathy is one of only two complementary and alternative medicines (CAMs) that are regulated under UK law. The other is chiropractic.     [tweetthis]#Osteopathy is 1 of only 2 complementary & alternative medicines regulated under UK law[/tweetthis]


 

6. Chiropractic was founded as a health profession in the US in 1895 by a Canadian called Daniel David Palmer. Palmer practiced magnetic healing and had no conventional medical training.

7. The earliest documented origins of physiotherapy (physical therapy) as a professional group date back to Per Henrik Ling, “Father of Swedish Gymnastics.” He founded the Royal Central Institute of Gymnastics (RCIG) in 1813 for massage, manipulation, and exercise. In 1894 four nurses in Great Britain formed the Chartered Society of Physiotherapy

8. Andrew Taylor Still, MD, DO (August 6, 1828 – December 12, 1917) was the founder of osteopathy and osteopathic medicine in 1874. He was also a physician and surgeon, author, inventor and Kansas territorial and state legislator.

9. OMT is typically used to treat musculoskeletal disorders. These include low back pain, neck pain. Also, pelvic pain, sports injuries, repetitive stress injuries RSI and tension headaches. While osteopathic and chiropractic techniques overlap, they’re not identical. As a general rule, chiropractic manipulation uses direct thrust techniques on the spine (HVLA). Osteopathic practitioners use other, gentler techniques, as well as HVLA.

Summary:

All three professions now have a similar medical training. They differ in professional training and emphasis during treatment.

Physiotherapists tend to focus on exercises. Chiropractors tend to focus on manipulation of the spine. Osteopaths tend to use exercise, manipulation and soft tissue massage as part of an integrated approach.

Male Infertility Treatment

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Male Infertility Treatment

The journey of the sperm to the egg is a long and hard one. Only the healthiest specimens will make it. And, of course, this journey has to occur at the right moment given that the egg is ready only once a month.

One in six couples has difficulty in having a family. In 40% of cases, the problems are related to the man.

Traditionally, the diagnosis of male infertility has relied on semen analysis. The SpermComet provides unique information that no other test offers.

Male Fertility

Did you know that the lifestyle of men as well as their age and different environmental factors play key roles in the conception process and male fertility in general?

 This is because the quality of a man’s sperm affects and the possibility of achieving pregnancy and the quality of sperm varies daily so timing is everything.

By measuring damaged DNA in individual sperm, the SpermComet Test can predict the success of infertility treatments and fast-track couples to the treatment most likely to succeed, leading to significantly reduced waiting times and improved chances of conception.

The head of the ‘Comet’ is undamaged DNA and the tail is damaged DNA. From the tail of the ‘Comet’ we can measure exactly the amount of damaged DNA in each individual sperm.

…………………………. and based on these results – a percentage of your sperm DNA damage – treatment can be administered at precisely the right time to maximise your chances of conception. Timing matters because:

  • On average, sperm take approximately 74 days to develop and another 20 additional days to be fertile.
  • In a cycle of 28 days, the woman usually ovulates 14 days after the start of menstruation. That is the most fertile day to have intercourse, and the most fertile week is that which goes from day 11 to 17. Although it is possible to conceive at any time if ovulation is irregular, the ideal scenario is to maintain sexual relations in this week.
  • The supplement we use at Susannah Makram Clinics is designed to be taken for a minimum period of three months. The initial results can  clinically observed from three months following the renewal of the sperm

DID YOU KNOW?
If you enjoyed reading this article, you can apply for <a href=”http://susannahmakram.com/membership/”>membership</a> and receive tailored reminders when further reading is available  on our NEWS PAGE – just choose The Body Youth Code of choice and we’ll do the rest! Psssst… this take 10-20 seconds max.


A combination therapy is available for men to take their lifestyle and habits into considered in a safe, private and clinical environment.


 

Naturopathic Consultation at a Susannah Makram clinics + Correct Male Fertility Testing 

= Time Saved and 100% clarity about treatment from this point onwards

Nutritional Supplement + The Naturopathic Portfolio = improved chances of conception. 
(more…)

Cold Pressed Juice, Juicing, Juicers

Differences Between Centrifugal and Cold Press Juicing

Soup and juice is for life. What’s juicing exactly? A Cold Press Juicer is also known as Masticating or Slow Juicer – see one in action here  Soup and juice isn’t a fashion. These are for lifelong nutrition. Our London Naturopath answers: Centrifugal Juicer or Centrifugal Juice Extractor?

Centrifugal (fast blade) and Cold Press (slow juicing)

 Traditionally a Centrifugal Juicer is the most common type of juicer. These typically utilise a fast-spinning metal blade that spins against a mesh filter, separating juice from flesh via centrifugal force. The juice and pulp are then separated into different containers.

Centrifugal Vs Cold Press Juicing

Centrifugal Vs Cold Press Juicing

Centrifugal Juicer – benefits

Pros

  • Easy to clean.
  • Can take most fruits and vegetables e.g. carrots and beets, cucumber and kale whole – so there’s limited chopping.
  • Great for juicing for smoothies e.g. Apples, Pears, Celery & Oranges
  • Easy and mobile to move around.

Centrifugal Juicer – disadvantages

Cons

  • Fast rotary blade can heat up the nutrients and enzymes in the juice. which can make the juice foamy and oxidise quicker and that can destroy some of the beneficial enzymes in the juice
  • Filter system often allows some bits in the juice
  • Tough to juice leafy greens such as spinach and kale
  • Low yield; As the blade is so fast and the machines are generally designed to work quickly, this creates a low yield leaving the pulp wasted and full of nutrition.

Cold Press Juice – Benefits

A Cold Press Juicer slowly compresses fruits and vegetables to ‘squeeze’ out the juice instead of using high-speed force to separate juice from pulp like a centrifugal juicer does.

Pros

  • Uses hydraulic pressure to extract juice, gaining a larger yield
  • Easier to juice leafy greens such as kale and spinach
  • Less likely to get bits in the juice
  • As no heat is applied to the fruit or vegetable, there is less oxidization and the enzymes and nutrients remain live for 3 to 5 days

Cons To Cold Press Juice Machine

Cons

  • A good cold press juicer can be a costly health investment
  • Can be heavy and relatively immobile
  • Using a cold press juicer can be a slow process

Buy Cold Press Juicer

Should you buy a Cold Press Juicer?

Juicing removes the fibre from your fruit and vegetables, which helps you absorb the nutrients quicker as discussed here

Whole foods are infinitely superior in vitamin and mineral quality – and oftentimes quantity – than nutritional supplements.

The bioavailability of nutrients varies from individual to individual which is why the Naturopathic Portfolio is simply concerned with your health needs.

The Naturopathic Portfolio is divided into:

1) Eat 2) Drink 3) Take 4) Make

No two portfolios are ever the same.

Best Juicer To Buy

Should you buy a juicer – Centrifugal Juicer or Cold Press?

  • There is an ethical debate over the food wastage involved with juicing
  • Fresh or raw food juice that is organic or cold pressed juices are the better option if you are consuming lots of sugary drinks, sodas or even store-bought “fresh” or organic juices, including green juice that is pre-packaged – always read the label
  • Making your own juice is a great way to know exactly what is going into your juice recipe
  • Store bought Cold Pressed Juice is likely made by a method that is called high-pressure pascalisation (HPP), which uses high-pressure chambers instead of heat to inhibit bacteria growth; HPP also naturally extends shelf life
  • Cold-pressing simply means that the juice is extracted by crushing the fruit or vegetable, and then pressing it to get the highest yield of juice. This is all done in a cold setting, so that no nutrients in the fruit or vegetable are damaged and enzymes stay intact
  • Pasteurisation means that the juice is heated to kill any bacteria, moulds and unwanted organisms. Many juices, not just green juices, are pasteurised because it extends the shelf life of a product

Making informed choices about your health is a good habit to employ at any age. This is the first step towards respecting your body. Being equipped with the knowledge to prevent illness and improve quality of life is invaluable.

Rock stars and DJs like the fabulous Boy George tweets his flavoursome raw food recipes – giving tips on where to source ingredients for vegan meals and other nutrient dense beverages and unique lunch, dinner and breakfast recipes.

There are infinite juice recipes and raw food recipes that you can find me tweeting about. These are inspirational as well as delicious – guaranteed to satiate hunger and also it is impossible not to find something to suit your taste buds – no matter what they find palatable!

Juice Cleanse – Juicer Vs Blender

Juice Cleanse

How to do a juice cleanse isn’t easy. You need kitchen appliances or a plan of action. A detox diet might be confused with a juice cleanse. While a juice cleanse isn’t easy, it’s not as difficult as it sounds. When we’ve been eating normally and then it’s just juice -that’s probably the hardest thing to get our head around.


Rest assured. Doing a juice cleanse or any so-called detox diet properly means hunger pangs will be satisfied.


Preparation is key. Is it right for me? Do we just wish to recreate our favourite organic cafe beverage, for example?

juice cleanse

juice cleanse

 

Juicer Vs Blending

Blenders and juicers are electrical appliances that are found in many household kitchens.

There are fundamental differences in the juice or smoothie end product when you are using a blender or juicer for a juice cleanse.

Key Points:

  • A juicer separates juice from fibre whereas a blender will blend all of the ingredients together.
  • A juicer or juicing household appliance has options that includes built-in: centrifugal, masticating, twin-gear, hand crank mechanisms
  • Blenders are typically selected based on options for speed – high – low
  • There is no pulp or fibre in the end product of juice from your juicer
  • There is pulp or fibre in the blender end product: smoothie

Both juices and smoothies can be made using recipes to enhance health. A tailored combination treatment might benefit from juices or smoothie to give the gut and our body a rest, to heal itself. Sometimes taking prescription medication can take its toll on our liver, for example. we might want to learn about ways to reduce toxicity levels and remain fit and well throughout your PHASE ONE treatment. Examples of treatment include e.g. chronic pain, itchy, flaky scalp, acne, unexplained tiredness or unexplained infertility.


At Susannah Makram Clinics we’re helping more and more families and business owners realise the potential through nutrition.


Hormonal imbalance, allergies, sensitivities or intolerances, ovulation disorders like PCOS, endometriosis, bacterial, fungal viral/post viral infections etc.

juice cleanse

Should You Buy a Juicer or Blender for a juice cleanse or for your health in general? Which is better?

It’s important that you understand what might be healthy to one person isn’t necessarily healthy for another bachelorarbeit ghostwriter kosten. It’s only with awareness of your health history and expected outlook for the future that you can take ownership of your health. You can decide whether juicing or blending smoothies is appropriate or preferable ghostwriting hausarbeit.

When taken at the right time of the day and using the right recipe or whole food prescription for you:

If you respect that food is medicine then you will take it as prescription aufsatz schreiben lassen. You’ll use this knowledge to make informed decisions about your health for life.

  1. Your Naturopathic Portfolio is designed to work for you.
  2. It answers every question to potential obstacles in your day-to-day lifestyle.
  3. It breaks each of these barriers down into simple, manageable tasks, in the four phases.
  4. It finds solutions that are palatable facharbeit schreiben lassen. We see circumstances at very stage in our story of health. Our expression of health is connected to a concern or condition but we aren’t defined by this.

Allergy epidemic

10 Things To Know About Your Child’s Allergies Now

London naturopath in Kensington and Chelsea Susannah sees complex cases. Acquired allergies and intolerances: are we expected to live with them?
Allergic conditions
have been diagnosed in 50% of UK children .        [tweetthis]In the UK 50% of children have been diagnosed with one or more #allergic conditions. [/tweetthis]      Allergies occur when the immune system reacts, by producing antibodies, to a foreign substance (allergen). When the immune system identifies this substance as harmful, this is an allergic reaction. The same substance does not cause a reaction in most people. Where do our children’s allergies come from? Why is this fast becoming an allergy epidemic?

The allergy epidemic. Fast Facts.

  1. Most to least common environmental allergens: pollen, grass, dust mites, molds or moulds and weeds. Food intolerance/sensitivity: generally less serious, often limited to digestive problems.
  2. Severity ranges from minor irritation to anaphylaxis —a potentially life-threatening emergency. 90% of food-allergic reactions are to peanuts, eggs, milk, (shell)fish, wheat, soy, tree nuts. Symptoms: h
ives, eczema, asthma, difficulty breathing, abdominal pain, vomiting, diarrhoea. Anaphylaxis also causes confusion, rapid heart beat/palpitations,  swelling of lips, tongue, throat, bluish skin, nausea, dizziness, fainting.

The allergy epidemic – understanding it gives us knowledge to combat the allergy epidemic.

  1. The pathophysiology of environmental allergies is fairly well understood. Allergies and asthma often occur together. Diagnosis can be made by history taking, physical exam and a Radioallergosorbent test (RAST) (prick-skin test). Results are nearly immediate. 50-60% of positive skin test results are also false positives. ImmunoCAP (blood test measuring levels of antibodies to specific food proteins). Results take up to one week. Highly controlled food challenges can render a definitive diagnosis.
  1. Introducing high allergenic foods to your child is advisable from 6 months. these foods should be introduced one at a time. leaving 3 days in between each new food is best. It is encouraged to breastfeed babies with eczema or a family history for 4 months+. Avoid cow’s milk or soy formulas. Hydrolysed protein formulas are best. “Hypoallergenic” formulas will not prevent but may delay allergy onset.
  1. Allergic reactions share a genetic link. Specific allergies do not. Studies show a gender-specific genetic link in inherited allergies.
  1. Quercetin can block the effects of histamine before they start. Recommended: 500 mg 1-2 times/ day, weeks before allergy season+ vitamin C.
  1. The best way to fight allergies is to avoid the offending allergen. This is not easy. Controlling your environment is a start. Keep homes cool, dry, non-smoking, low-odour and ventilated (use a pollen-proof screen). If keeping carpets think small, vacuum and dust often. Launder sheets. pillowcases (55°C water) and wash indoor pets, especially cats, after discussing this with your vet weekly. Replace furnaces and air-conditioner filters while in use. Wash stuffed animals (55°C water/place in a plastic bag in the freezer for a few days) monthly.
Allergy Epidemic

Allergy Epidemic

  1. Leukotriene inhibitors and steroids sprayed in the nose can help with symptoms. Conventionally anti-histamines (diphenhydramine; check side–effects) with/out “Mast cell stabilisers” or steroids are given.
  • Changing medication prevents building a tolerance to them.
  1. Subcutaneous immunotherapy (SCIT) or allergy shots are injections of allergens given at increasing dosages. Typical treatment: weekly shots for the first 3-6 months, then monthly for 3-5 years.
  • Sublingual Immunotherapy (SLIT) – a preventive treatment – is not as effective as shots but is safer, since there’s less risk of side effects (anaphylaxis).
  • In the case of severe allergies, carry an EpiPen in case of anaphylaxis.
  1. Most allergies can’t be cured. However, potentially life-threatening peanut allergies have recently essentially cured 9/10 recipients of a new treatment using a dose of a probiotic, together with peanut protein in increasing amounts.

Susannah Makram is a registered Naturopath. Her diagnostic skills are recognised as a registered Osteopath. Her interests in Naturopathic Nutrition, nutrigenomics, epigenetics and the functional approach to healthcare make her Portfolio treatment Safe, Clinical, Practical, Effective.

When you correctly identify your child’s allergies, Susannah will help you find a suitable strategy to help manage your child’s allergies. Managing your child’s allergy symptoms need not be a lifelong burden.

15 Fertility Rate Facts To Know Now

Fertility Rate – 15  Facts  – What You Need to Know Now If You Ever Want Kids

It’s likely you’re unsure of your current fertility rate. Modern times are affecting our fertility rates. Our fertility rates are subject to changing trends and patterns. We know lifestyle choices during pregnancy affect the health of your baby. What about food, exercise and other lifestyle choices we’re making today? Do they affect our fertility rate, our potential future?

These are choices we are making today.

“15 Fertility Rate Facts To Know Now”


‘One in six couples has problems starting a family’       [tweetthis hidden_hashtags=”#fertility #pregnancy”]’One in six couples has problems starting a family’ [/tweetthis]


In a word, yes. Lifestyle factors can affect a woman’s chances of getting pregnant. This is by natural and assisted conception. It’s not just women, male partners affect chances of pregnancy too. Your fertility rate or your current fertility profile should enable you to face facts.

Why Fertility Rates Are On The Decline

Let’s get clued up now. Here’s why:

  1. One in six couples has difficulty having a baby – in 40 per cent of these cases the difficulty is associated with the man.         [tweetthis]In 40% of #infertility cases, the cause, for 1 in 6 couples, is associated with the man[/tweetthis]

Equal responsibility is about sharing knowledge and open communication. 

  1. Timing is just about everything when it comes to fertility –

In a normal cycle of 28 days, the woman ovulates normally on day 14 (14 days after the start of menstruation). The most fertile day would be on day 14 and the most fertile week is that which goes from day 11 to 17.

  1. The medical definition of infertility is the failure to conceive following twelve months of regular unprotected intercourse After this time your GP will refer you for:

A blood test to measure ovulation is required. The most common cause of ovulation problems is polycystic ovaries.

Chlamydia can cause pelvic inflammatory disease and fertility problems. So this might be tested for also (vaginal swab or urine test). Male sperm count and motility are measured at this stage from a sperm sample.

  1. Secondary infertility accounts for 60 percent of infertility cases – that is, when a couple has trouble conceiving after they’ve already had a baby or more — is more common than primary infertility, when first-timers have trouble.
  1. Women are at their most fertile between the ages of 20-24

There are both advantages and disadvantages to giving birth at different ages. Overall, being healthy parents puts you in good stead.

 

Female Infertility

15 Fertility Rate Facts To Know Now

  1. Female fertility begins to decline at age 30.

If you are over 40, you may want to start your quest for a second pregnancy with a fertility expert on hand. Similarly, if your partner is over 40, you may want to get a specialist on board from the beginning.

  1. Sperm DNA damage has been identified as a major contributor to male infertility        [tweetthis]Sperm DNA damage has been identified as a major contributor to male #infertility[/tweetthis]

The quality and quantity of the sperm diminishes from the age of 25. Damage to sperm DNA (sperm DNA fragmentation) affects every fertility checkpoint and can increase the risk of miscarriage.

The SpermComet assay is a second generation sperm DNA test. It is the ONLY test that can measure the extent of damage in individual sperm.

  1. Men Do Have a Biological Clock

Males can produce viable sperm — and father babies — well into their AARP years. However, older men are more likely to have fertility issues. Also, due to dipping testosterone levels, there is a decrease in quantity and quality of sperm. Sperm strength, motility and other factors.

Male Fertility Testing

Male Fertility Testing

 

  1. More than half of all pregnancies conceived through IVF in women over age forty are produced through donor eggs. Egg freezing or (new techniques like) vitrification is not a taboo subject any more.

 

  1. Female infertility is typically caused by one or more of these factors:

Damage to fallopian tubes (tubal infertility)
Endometriosis
Uterine or cervical causes
Ovulation disorders

 

  1. Success in assisted conception is dependent on the quality of the sperm and eggs

Egg quality falls with age. Hence, one of the strongest predictors of whether an IVF cycle will be successful is the age of the woman. A major cause of this is the development of chromosomal abnormalities in the egg as it matures, which can in turn be passed on to the embryo.

Genetic screening is available to help choose the best embryo(s) to replace and thus increase the pregnancy rate.

 

  1. Cough medicine can help you get pregnant, laptops and briefs can impair sperm production. Saliva is a sperm Killer & position doesn’t really matter. Common Chemicals Are Fertility Inhibitors

Expectorants loosen up mucus in your chest but they are also able to loosen up cervical mucus – if antihistamine-free. Looser cervical mucus is easier for sperm to hitch a ride in!

Not all bodily fluids get along. In fact saliva is a sperm killer. The truth is most lubricants and massage oils are fertility unfriendly. So it is best to go without when you are baby making.

Some studies have shown that the now-infamous Bisphenol A (BPA) can decrease fertility in women. Perfluoronated chemicals (PFCs), used in Teflon, have also been shown to affect the menstrual cycle.

15 Fertility Rate Facts To Know Now Continued…

  1. Both Prescription & Recreational Drugs affect fertility as does smoking cigarettes

Some antidepressants (like SSRI’s) can raise a woman’s serum prolactin level. This can interfere with normal ovulation. Even certain antiemetic (anti-nausea) medications can alter prolactin levels.

Using any drugs, even cannabis, can affect the menstrual cycle. Heavier drugs like opiates have been shown to suppress the reproductive cycle. They affect the centers of the brain that control release of the female hormones.

Smoking cigarettes – even secondhand smoke – has been shown to reduce fertility time and time again.

 

When IVF Fails

When IVF Fails

 

  1. An Unhealthy body weight may prevent you from having children

Being overweight, obese or underweight can have negative consequences for one’s ability to conceive. This is because obesity can interfere with normal hormone function and fertility. The only treatment available to successfully reverse sperm DNA damage is largely dependent on two things. These are nutrition and nutritional supplementation.

  1. Fertility is a sensitive subject for a reason and there are support groups. Fertility and therapeutic counselling is also available for couples trying to conceive naturally. These are also there for individuals and couples using assisted fertility methods.

15 Fertility Rate Facts To Know Now

Susannah understands that when a couple hears a diagnosis of  ‘unexplained infertility’ it’s incredibly frustrating. When natural conception or assisted reproductive fertility treatment haven’t been successful, it’s difficult to hear. The most common assisted fertility treatment is IVF.  We put together 15 fertility rate facts to know now because you want to understand what the next steps are. You want to move forward from this, when ready. You should be able to discuss these steps and come to a decision together.


Nutrition impacts 80% of your modern lifestyle. This impacts every single factor affecting fertility. This goes for both men and women. If you  take ownership of your health you can make sure that the right changes impact you and your partner for the best.


 


Safe, clinical, practical and effective.


Call  020 7060 3181